Antibacterial Properties of Flavonoids from Kino of the Eucalypt Tree, Corymbia torelliana
| Autor: | Peter Brooks, Klrissa Streeter, Mohammad Katouli, Motahareh Nobakht, Stephen J. Trueman, Helen M. Wallace |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
antibiotic resistance food.ingredient natural products 030106 microbiology Flavonoid Corymbia citriodora Plant Science traditional medicine medicine.disease_cause Article ethnobotany 03 medical and health sciences chemistry.chemical_compound Minimum inhibitory concentration food Corymbia torelliana Botany medicine antimicrobial activity cytotoxicity Eucalyptus Pseudomonas aeruginosa stingless bees Tetragonula Candida albicans Ecology Evolution Behavior and Systematics chemistry.chemical_classification Ecology biology Flavanonol biology.organism_classification Antimicrobial 030104 developmental biology chemistry QK1-989 |
| Zdroj: | Plants; Volume 6; Issue 3; Pages: 39 Plants, Vol 6, Iss 3, p 39 (2017) Plants |
| ISSN: | 2223-7747 |
| DOI: | 10.3390/plants6030039 |
| Popis: | Traditional medicine and ecological cues can both help to reveal bioactive natural compounds. Indigenous Australians have long used kino from trunks of the eucalypt tree, Corymbia citriodora, in traditional medicine. A closely related eucalypt, C. torelliana, produces a fruit resin with antimicrobial properties that is highly attractive to stingless bees. We tested the antimicrobial activity of extracts from kino of C. citriodora, C. torelliana × C. citriodora, and C. torelliana against three Gram-negative and two Gram-positive bacteria and the unicellular fungus, Candida albicans. All extracts were active against all microbes, with the highest activity observed against P. aeruginosa. We tested the activity of seven flavonoids from the kino of C. torelliana against P. aeruginosa and S. aureus. All flavonoids were active against P. aeruginosa, and one compound, (+)-(2S)-4′,5,7-trihydroxy-6-methylflavanone, was active against S. aureus. Another compound, 4′,5,7-trihydroxy-6,8-dimethylflavanone, greatly increased biofilm formation by both P. aeruginosa and S. aureus. The presence or absence of methyl groups at positions 6 and 8 in the flavonoid A ring determined their anti-Staphylococcus and biofilm-stimulating activity. One of the most abundant and active compounds, 3,4′,5,7-tetrahydroxyflavanone, was tested further against P. aeruginosa and was found to be bacteriostatic at its minimum inhibitory concentration of 200 µg/mL. This flavanonol reduced adhesion of P. aeruginosa cells while inducing no cytotoxic effects in Vero cells. This study demonstrated the antimicrobial properties of flavonoids in eucalypt kino and highlighted that traditional medicinal knowledge and ecological cues can reveal valuable natural compounds. |
| Databáze: | OpenAIRE |
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