Effects of Prolonged Starvation on Plasma Free Fatty Acid Levels and Fatty Acid Composition of Myocardial Total Lipids in the Rat
| Autor: | Joseph Sampugna, Armand J. Gold, Steven R. Yaffe |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
medicine.medical_specialty
Heart Ventricles Medicine (miscellaneous) Fatty Acids Nonesterified Biology In vivo Internal medicine medicine Animals Humans chemistry.chemical_classification Starvation Nutrition and Dietetics Myocardium Fatty Acids Extraction (chemistry) Fatty acid Lipid metabolism Lipid Metabolism Rats Endocrinology chemistry Fatty Acids Unsaturated lipids (amino acids peptides and proteins) Composition (visual arts) Gas chromatography medicine.symptom Polyunsaturated fatty acid |
| Zdroj: | The Journal of Nutrition. 110:2490-2496 |
| ISSN: | 0022-3166 |
| DOI: | 10.1093/jn/110.12.2490 |
| Popis: | Experiments were carried out on male rat fed ad libitum or starved for a period of 7 days. Plasma levels of free fatty acids (FFA) and the quantity and composition of fatty acids in total lipids of heart ventricular tissue in vivo were analyzed by gas liquid chromatography (GLC). In addition, FFA extraction ratios and uptake rates were determined in isolated perfused hearts using the classical Langendorff technique. After 7 days of starvation, distribution and concentrations obtained for total lipid fatty acids from heart ventricles of starved animals were substantially different from those of controls. In particular, 20:5 and 22:6 carbon polyunsaturated fatty acids were significantly elevated. Also, total plasma FFA level was elevated and FFA extraction ratios were increased as a result of prolonged starvation. Accumulation of 20- and 22-carbon polyunsaturated fatty acids observed in ventricles of starved rats may have resulted from increased availability and extraction of FFA. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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