FDG Imaging of Lung Nodules: A Phantom Study Comparing SPECT, Camera-based PET, and Dedicated PET
| Autor: | Charles M. Laymon, R E Coleman, Timothy G. Turkington |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Lung Diseases
Single-photon emission computed tomography Imaging phantom Fluorodeoxyglucose F18 Image Processing Computer-Assisted Humans Medicine Gamma Cameras Radiology Nuclear Medicine and imaging Lung Tomography Emission-Computed Single-Photon medicine.diagnostic_test Phantoms Imaging business.industry Mediastinum Signal Processing Computer-Assisted Pet imaging Thorax Image Enhancement Body contour medicine.anatomical_structure Positron emission tomography Radiopharmaceuticals business Nuclear medicine Correction for attenuation Tomography Emission-Computed |
| Zdroj: | Radiology. 210:823-828 |
| ISSN: | 1527-1315 0033-8419 |
| Popis: | To evaluate 2-[fluorine-18]fluoro-2-deoxy-D-glucose (FDG) imaging of simulated lung nodules in a realistic chest phantom by using attenuation-corrected and non-attenuation-corrected 511-keV single photon emission computed tomography (SPECT), camera-based positron emission tomography (PET), and dedicated PET imaging.Spheres with diameters of 6, 10, 13, and 22 mm were placed in the lungs of an anthropomorphic chest phantom to simulate nodules. The lungs, nodules, chest wall, and mediastinum were filled with fluorine-18 activities based on the average radionuclide concentrations in those structures from analysis of attenuation-corrected dedicated FDG PET scans. The image sets were evaluated visually and quantitatively by using contrast and signal-to-noise ratios.Attenuation correction reduced the artificially high apparent uptake in the lungs, restored the spherical shape to the nodules, and provided an accurate outer body contour with appropriate intensity. Dedicated PET depicted all four nodules, camera-based PET depicted the three largest nodules, and SPECT depicted the two largest nodules. Lesion contrast was better on the attenuation-corrected images than on the non-attenuation-corrected images. The signal-to-noise ratio generally was improved with attenuation correction.Attenuation correction results in many changes in the images and improves lesion detection. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|