Solid-State Characterization and Compatibility Studies of Penciclovir, Lysine Hydrochloride, and Pharmaceutical Excipients

Autor: Larissa S. Bernardi, Paulo R. Oliveira, Camila Tita Nogueira, Isabela Fanelli Barreto Biscaia, Rafaela Zielinski Cavalheiro de Meira, Fábio S. Murakami
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Cetostearyl alcohol
02 engineering and technology
thermogravimetry
compatibility
01 natural sciences
lcsh:Technology
Article
chemistry.chemical_compound
Differential scanning calorimetry
medicine
General Materials Science
characterization
Fourier transform infrared spectroscopy
lcsh:Microscopy
lcsh:QC120-168.85
Wax
lysine
excipients
Methylparaben
lcsh:QH201-278.5
010405 organic chemistry
lcsh:T
021001 nanoscience & nanotechnology
0104 chemical sciences
Thermogravimetry
penciclovir
chemistry
lcsh:TA1-2040
visual_art
Penciclovir
visual_art.visual_art_medium
lcsh:Descriptive and experimental mechanics
lcsh:Electrical engineering. Electronics. Nuclear engineering
differential scanning calorimetry
0210 nano-technology
lcsh:Engineering (General). Civil engineering (General)
lcsh:TK1-9971
Propylparaben
Nuclear chemistry
medicine.drug
Zdroj: Materials
Volume 12
Issue 19
Materials, Vol 12, Iss 19, p 3154 (2019)
ISSN: 1996-1944
DOI: 10.3390/ma12193154
Popis: The physical and chemical characterization of the solid-state properties of drugs and excipients is fundamental for planning new formulations and developing new strategies for the treatment of diseases. Techniques such as differential scanning calorimetry, thermogravimetry, X-ray powder diffraction, Fourier transform infrared spectroscopy, and scanning electron microscopy are among the most commonly used techniques for these purposes. Penciclovir and lysine are individually used to treat the herpes virus. As such, the development of a formulation containing both drugs may have therapeutic potential. Solid-state characterization showed that both penciclovir and lysine were crystalline materials with melting points at 278.27 °
C and 260.91 °
C, respectively. Compatibility studies of penciclovir and lysine indicated a possible interaction between these substances, as evidenced by a single melting point at 253.10 °
C. The compatibility of several excipients, including ethylenediaminetetraacetic acid, cetostearyl alcohol, sodium lauryl sulphate, di-tert-butyl methyl phenol, liquid petrolatum, methylparaben, nonionic wax, paraffin, propylene glycol, and propylparaben, was evaluated in ternary (penciclovir-lysine-excipient) mixtures (1:1:1, w/w/w) to determine the optimal formulation. The developed formulation was stable under accelerated and ambient conditions, which demonstrated that the interaction between penciclovir and lysine was suitable for the development of a formulation containing both drugs.
Databáze: OpenAIRE
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