PENGARUH PEMBERIAN EKSTRAK SAMBILOTO (Andrographis Paniculata) TERHADAP GAMBARAN HISTOPATOLOGI GINJAL YANG DIINDUKSI GENTAMISIN PADA TIKUS (Rattus norvegicus)
| Autor: | Iwan Sahrial Hamid, Lianny Nangoi, Thomas Valentinus Widiyatno, Dewa Ketut Meles, Kuncoro Puguh Santoso, Anggi Dwi Nugrahani |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Treated group
medicine.medical_specialty Traditional medicine Sambiloto extract business.industry nephrotoxicity Significant difference Renal histopathology Staining Nephrotoxicity gentamicin-induced renal histopathology medicine Histopathology Gentamicin Intramuscular injection business medicine.drug acute renal failure (ARF) |
| Zdroj: | Journal of Basic Medical Veterinary; Vol. 8 No. 1 (2019): Journal of Basic Medical Veterinary, Juni 2019; 29-34 |
| ISSN: | 2302-6820 2774-9959 |
| Popis: | This research was aimed to know the effect of leaves extract of sambiloto as a nephroprotector on renal histopathology features induced by gentamicin in white rats (Rattus norvegicus). The effect of leaves extract of sambiloto was tested in 25 rats. Twenty five male white rat were randomly divided into five groups; K- as negative control was given carboxy methyl cellulosa in 15 days, P0 was given carboxyl methyl cellulosa in 15 days, P1 was given leaves extract of sambiloto of 177 mg/kg bw/day/po in 15 days, P2 was given leaves extract of sambiloto of 189 mg/kg bw/day/po in 15 days, P3 was given leaves extract of sambiloto of 239,5 mg/kg bw/day/po in 15 days. On the 15 day of experimental, P0, P1, P2, P3 was given 200 mg/kg bw of gentamicin. Gentamicin solutions on P0, P1, P2 and P3 treated through intramuscular injection. After 24 hours of gentamicin induced, take the rats renal by laparotomy and then making preparations histopathology with staining Haematoxylin-Eosin (HE). Based on the result of Kruskall-Wallis statistical analysis on renal histopathology showed this research that the treatment have significant difference (p < 0,05). The leaves extract of sambiloto treated group (P3) gave the best value on the renal morfology, it gave a good effects in preventing nephrotoxicity in white rats. |
| Databáze: | OpenAIRE |
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