Anti-leishmanial and immunomodulatory activities of extracts from Portulaca hirsutissima and Portulaca werdermannii
| Autor: | Ricardo Ribeiro dos Santos, Jorge Mauricio David, Juceni P. David, Ana Maria Giulietti, Luciano Paganucci de Queiroz, Milena Botelho Pereira Soares, Alice Costa Kiperstok, José Fernando Oliveira Costa |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Trypanosoma cruzi Antiprotozoal Agents Portulaca Lymphocyte proliferation Pharmacognosy law.invention Inhibitory Concentration 50 Mice Parasitic Sensitivity Tests law parasitic diseases Drug Discovery medicine Animals Immunologic Factors Lymphocytes Axenic Portulacaceae Cell Proliferation Leishmania Pharmacology Mice Inbred BALB C biology Traditional medicine Plant Extracts Leishmaniasis General Medicine biology.organism_classification medicine.disease Biochemistry Leishmaniasis Visceral Female Phytotherapy |
| Zdroj: | Fitoterapia. 78:510-514 |
| ISSN: | 0367-326X |
| Popis: | Ethyl acetate and chloroform extracts from aerial parts of Portulaca werdermannii and P. hirsutissima were tested in lymphoproliferation assays and axenic cultures of Leishmania amazonensis and Trypanosoma cruzi. Both extracts of P. werdermannii and P. hirsutissima had a potent inhibitory activity on lymphocyte proliferation. On the contrary, only the chloroformic extract of both plants inhibited L. amazonensis growth, without effect on T. cruzi cultures. These results indicate these Portulaca species as potential sources of new active molecules for the treatment of leishmaniasis and immune-mediated pathologies. |
| Databáze: | OpenAIRE |
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