Milacemide enhances memory storage and alleviates spontaneous forgetting in mice
| Autor: | David Quartermain, Jeffrey Sheu, Triet Nuygen, Robert L. Herting |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
Monoamine Oxidase Inhibitors education Clinical Biochemistry Toxicology Biochemistry Receptors N-Methyl-D-Aspartate Behavioral Neuroscience chemistry.chemical_compound Mice Memory Acetamides medicine Avoidance Learning Animals Amino Acids Biological Psychiatry Pharmacology Forgetting Milacemide Memoria Glutamate receptor chemistry Mechanism of action 2-Amino-5-phosphonovalerate Facilitation NMDA receptor medicine.symptom Passive avoidance Psychology Neuroscience |
| Zdroj: | Pharmacology, biochemistry, and behavior. 39(1) |
| ISSN: | 0091-3057 |
| Popis: | The objective of this study was to evaluate the effectiveness of milacemide as a memory-enhancing drug in mice. Experiment 1 showed that forgetting of active avoidance learning produced by a 14-day training to test delay could be alleviated by milacemide (10 mg/kg) administered before the retention test. Experiment 2 demonstrated that the same dose of milacemide could also attenuate spontaneous forgetting of passive avoidance learning, thereby ruling out nonspecific effects as an explanation for the enhancement of performance following pretesting drug administration. A third experiment showed that the facilitation of retrieval induced by milacemide could be blocked by the NMDA receptor antagonist AP-7, suggesting that the effects of milacemide on memory may be mediated by NMDA receptor activation. A final experiment demonstrated that retention was improved when milacemide was administered immediately following active avoidance training, indicating that the drug can also facilitate remembering by its actions on consolidation and storage processes. |
| Databáze: | OpenAIRE |
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