Development of Alzheimer-disease neuroimaging-biomarkers using mouse models with amyloid-precursor protein-transgene expression
| Autor: | Stefan J. Teipel, Johannes Thome, Ralph Buchert, Jens Pahnke, Harald Hampel |
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| Rok vydání: | 2011 |
| Předmět: |
Genetically modified mouse
Transgene Neuroimaging Plaque Amyloid genetics [Alzheimer Disease] Mice Transgenic Translational research Disease Mice Amyloid beta-Protein Precursor Alzheimer Disease pathology [Brain] medicine Amyloid precursor protein Animals Humans Dementia ddc:610 pathology [Plaque Amyloid] Radionuclide Imaging diagnostic imaging [Brain] biology General Neuroscience diagnosis [Alzheimer Disease] Brain medicine.disease Disease Models Animal genetics [Amyloid beta-Protein Precursor] metabolism [Brain] biology.protein diagnostic imaging [Plaque Amyloid] Molecular imaging Alzheimer's disease methods [Neuroimaging] Psychology diagnostic imaging [Alzheimer Disease] Neuroscience Biomarkers metabolism [Biomarkers] |
| Zdroj: | Progress in neurobiology 95(4), 547-556 (2011). doi:10.1016/j.pneurobio.2011.05.004 |
| ISSN: | 0301-0082 |
| DOI: | 10.1016/j.pneurobio.2011.05.004 |
| Popis: | There are important recent developments in Alzheimer's disease (AD) translational research, especially with respect to the imaging of amyloid pathology in vivo using MRI and PET technologies. Here we exploit the most widely used transgenic mouse models of amyloid pathology in order to relate the imaging findings to our knowledge about the histopathological phenotype of these models. The development of new diagnostic criteria of AD necessitates the use of biological markers to diagnose AD even in the absence of overt dementia or early symptomatic mild cognitive impairment. The validity of the diagnosis will depend on the availability of an in vivo marker to reflect underlying neurobiological changes of AD. Transgenic models with essential features of AD pathology and mechanisms provide a test setting for the development and evaluation of new biological imaging markers. Among the best established imaging markers of amyloid pathology in transgenic animals are high-field MRI of brain atrophy, proton spectroscopy of neurochemical changes, high-field MRI of amyloid plaque load, and in vivo plaque imaging using radio-labelled ligands with PET. We discuss the implications of the findings as well as the methodological limitations and the specific requirements of these technologies. We furthermore outline future directions of transgene-imaging research. Transgene imaging is an emerging area of translational research that implies strong multi- and interdisciplinary collaborations. It will become ever more valuable with the introduction of new diagnostic standards and novel treatment approaches which will require valid and reliable biological markers to improve the diagnosis and early treatment of AD patients. |
| Databáze: | OpenAIRE |
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