Age-Related Features of Cytoflavin Effectiveness During Experimental Myocardial Ischemia
| Autor: | V. V. Rumbesht, T. V. Gorbach, N. I. Zhernakova, O. V. Romashchenko |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Niacinamide medicine.medical_specialty Cardiotonic Agents Myocardial ischemia Flavin Mononucleotide Energy reserves Myocardial Reperfusion Injury General Biochemistry Genetics and Molecular Biology Adenosine Triphosphate Internal medicine Age related Blood plasma Animals Medicine Myocytes Cardiac cardiovascular diseases Rats Wistar Mitochondrial enzymes Cardioprotection business.industry Myocardium Age Factors Succinates General Medicine Hypoxia (medical) Mitochondria Rats Surgery Enzyme Activation Drug Combinations Endocrinology medicine.symptom business Inosine Diphosphate |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 156:785-788 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-014-2450-z |
| Popis: | Administration of Cytoflavin to young rats with experimental myocardial ischemia was followed by activation of mitochondrial enzymes and significant accumulation of ATP in the myocardium and blood plasma, but did not modulate the stability of cardiomyocyte membranes and signs of hypoxia. Cytoflavin increased the severity of metabolic disorders and depleted the energy reserves of cells in old rats with myocardial ischemia. |
| Databáze: | OpenAIRE |
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