Ovarian Embryonal Carcinoma in a Dog
| Autor: | Damiano Stefanello, Mario Caniatti, Valeria Grieco, Giuliano Ravasio, Maurizio Longo, B. Banco, Debora Groppetti, D. De Zani, Alessandro Pecile, Roberta Ferrari, Stefano Faverzani |
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| Rok vydání: | 2017 |
| Předmět: |
Pathology
medicine.medical_specialty Necrosis 040301 veterinary sciences Exploratory laparotomy medicine.medical_treatment Biology Pathology and Forensic Medicine 0403 veterinary science 03 medical and health sciences Cytokeratin 0302 clinical medicine Dogs Carcinoma Embryonal Ascites medicine Animals Dog Diseases Ovarian Neoplasms General Veterinary 04 agricultural and veterinary sciences Anatomy Neoplasms Germ Cell and Embryonal Abdominal mass Doberman Pinscher Placental alkaline phosphatase 030220 oncology & carcinogenesis Female medicine.symptom Differential diagnosis |
| Zdroj: | Journal of comparative pathology. 157(4) |
| ISSN: | 1532-3129 |
| Popis: | A 17-month-old female doberman pinscher was referred for an abdominal mass and ascites. Exploratory laparotomy revealed the presence of a large neoplastic mass replacing the right ovary and associated with multiple mesovarian, mesometrial and peritoneal nodules. An ovariohysterectomy was performed. Grossly, the tumour was soft and multilocular with large areas of haemorrhage and necrosis. Microscopically, it was infiltrative and composed of round and polygonal cells arranged respectively in solid sheets or forming distorted tubular structures separated by thick fibrovascular septae. Tubules contained necrotic debris, proteinaceous fluid or small endoluminal papillary structures. Marked cellular atypia, multiple neoplastic emboli and high mitotic count were observed. Immunohistochemically, the round cells uniformly expressed placental alkaline phosphatase, while the polygonal cells arranged in tubules and papillae expressed cytokeratin (CK) AE1/AE3 and CK7. A final diagnosis of metastasizing ovarian embryonal carcinoma (EC), a primitive germ cell tumour characterized by rudimentary epithelial differentiation was made. Canine ovarian EC should be considered as a differential diagnosis for undifferentiated aggressive ovarian tumours in young dogs. |
| Databáze: | OpenAIRE |
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