Changes on the physiological lactonase activity of serum paraoxonase 1 by a diet intervention for weight loss in healthy overweight and obese women
| Autor: | Yoshiko Sano, Kokoro Tsuzaki, Kazuhiko Kotani, Jennifer Taing, Yoshinobu Kiso, Satoshi Kimura, Kahori Egawa, Alejandro Gugliucci, Yoshinori Kitagawa, Yukiyo Matsuoka, Makiko Yoshimura, John Schulze, Naoki Sakane, Chika Horikawa |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Clinical Biochemistry Medicine (miscellaneous) Blood lipids Overweight high-density lipoprotein Arylesterase chemistry.chemical_compound BMI High-density lipoprotein Weight loss Internal medicine medicine Lactonase Nutrition and Dietetics biology Chemistry Paraoxonase low caloric diet Endocrinology low-density lipoprotein biology.protein lipids (amino acids peptides and proteins) Original Article weight reduction medicine.symptom Body mass index |
| Zdroj: | Journal of Clinical Biochemistry and Nutrition |
| ISSN: | 1880-5086 |
| Popis: | Low caloric diet (LCD) is used for weight loss. Paraoxonase 1 (PON-1) is associated with the antioxidant functions of high-density lipoprotein (HDL). Among limited data on the relationships between obesity and PON-1, there has been no study on the effects of a stand-alone LCD on the physiological lactonase activity of PON-1. We investigated the prospective effects of LCD intervention (2 months) for weight loss on serum PON-1 activities (lactonase, arylesterase [mono-esterase] and tri-esterase) and HDL cholesterol (HDL-C), and their association with low-density lipoprotein cholesterol (LDL-C) in overweight and non-morbidly obese but otherwise healthy women (n = 30; mean age, 50.3 years; mean body mass index [BMI], 28.5 kg/m(2)). In addition to the data such as BMI, blood pressure, blood glucose and lipids, PON-1 activities were examined between pre- and post-intervention. The intervention reduced all metabolic outcomes, and PON-1 lactonase activity (determined with 5-[thiobutyl]butyrolactone) significantly decreased by 6.1%, paralleled by arylesterase (by 7.3%) and tri-esterase (by 7.8%). In multiple regression analysis, the percent change of PON-1 lactonase was significantly, positively and independently correlated to that of LDL-C (beta = 0.51), HDL-C (beta = 0.40), and BMI (beta = 0.37). Our results showed that the solo diet treatment on weight loss might reduce serum PON-1 lactonase activity with reduced HDL-C and LDL-C. The relationship between the lactonase and LDL-C may be adaptive, plausibly hypothesizing less need for PON-1 activity as an antioxidant property to protect lipoproteins. Further research is needed to confirm this prediction. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|