Phase Correction for Absorption Mode Two-Dimensional Mass Spectrometry
| Autor: | Maria A. van Agthoven, Marc-André Delsuc, Kathrin Breuker |
|---|---|
| Přispěvatelé: | Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), CASC4DE S.A.S (CASC4DE), University of Innsbruck, Leopold Franzens Universität Innsbruck - University of Innsbruck, DELSUC, Marc-André |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
analytical_chemistry
Phase (waves) Analytical chemistry Pharmaceutical Science 010402 general chemistry Tandem mass spectrometry Mass spectrometry 01 natural sciences Article Analytical Chemistry Ion symbols.namesake QD241-441 phase correction Dimension (vector space) [CHIM] Chemical Sciences tandem mass spectrometry Drug Discovery [CHIM]Chemical Sciences absorption mode Physical and Theoretical Chemistry mass spectrometry Physics 010401 analytical chemistry Organic Chemistry 0104 chemical sciences Fourier transform two-dimensional Chemistry (miscellaneous) Mass spectrum symbols Molecular Medicine data processing Absorption (chemistry) |
| Zdroj: | Molecules Molecules, MDPI, 2021, 26 (11), pp.3388. ⟨10.3390/molecules26113388⟩ Volume 26 Issue 11 Molecules, 2021, 26 (11), pp.3388. ⟨10.3390/molecules26113388⟩ Molecules, Vol 26, Iss 3388, p 3388 (2021) |
| ISSN: | 1420-3049 |
| DOI: | 10.5281/zenodo.4884410 |
| Popis: | Two-dimensional mass spectrometry (2D MS) is a tandem mass spectrometry method that relies on manipulating ion motions to correlate precursor and fragment ion signals. 2D mass spectra are obtained by performing a Fourier transform in both the precursor ion mass-to-charge ratio (m/z) dimension and the fragment ion m/z dimension. The phase of the ion signals evolves linearly in the precursor m/z dimension and quadratically in the fragment m/z dimension. This study demonstrates that phase-corrected absorption mode 2D mass spectrometry improves signal-to-noise ratios by a factor of 2 and resolving power by a factor of 2 in each dimension compared to magnitude mode. Furthermore, phase correction leads to an easier differentiation between ion signals and artefacts, and therefore easier data interpretation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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