Bidirectional Brain‐gut‐microbiota Axis in increased intestinal permeability induced by central nervous system injury

Autor: Xiaojin Li, Xueli Li, Yanjun Zhang, Pengwei Zhuang, Cong‐ying Wang, Xin‐yu You, Yuanyuan Sheng
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Hypothalamo-Hypophyseal System
central nervous system injury
Central nervous system
hypothalamic‐pituitary‐adrenal axis
Pituitary-Adrenal System
Context (language use)
Inflammation
Review Article
Gut flora
Enteric Nervous System
Permeability
03 medical and health sciences
0302 clinical medicine
Immune system
Central Nervous System Diseases
Physiology (medical)
Medicine
Animals
Humans
Pharmacology (medical)
Pharmacology
Intestinal permeability
biology
business.industry
autonomic nervous system
Brain
biology.organism_classification
medicine.disease
Gastrointestinal Microbiome
Psychiatry and Mental health
Autonomic nervous system
030104 developmental biology
medicine.anatomical_structure
Intestinal Absorption
Immunology
Enteric nervous system
medicine.symptom
business
increased intestinal permeability
030217 neurology & neurosurgery
Zdroj: CNS Neuroscience & Therapeutics
ISSN: 1755-5949
1755-5930
Popis: Central nervous system injuries may lead to the disorders of the hypothalamic‐pituitary‐adrenal axis, autonomic nervous system, and enteric nervous system. These effects then cause the changes in the intestinal microenvironment, such as a disordered intestinal immune system as well as alterations of intestinal bacteria. Ultimately, this leads to an increase in intestinal permeability. Inflammatory factors produced by the interactions between intestinal neurons and immune cells as well as the secretions and metabolites of intestinal flora can then migrate through the intestinal barrier, which will aggravate any peripheral inflammation and the central nervous system injury. The brain‐gut‐microbiota axis is a complex system that plays a crucial role in the occurrence and development of central nervous system diseases. It may also increase the consequences of preventative treatment. In this context, here we have summarized the factors that can lead to the increased intestinal permeability and some of the possible outcomes.
Databáze: OpenAIRE
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