Chemotherapy in combination with stereotactic body radiation therapy (SBRT) for oligometastatic pancreatic cancer
| Autor: | Ivan Vladimirovich Rykov, Mikhail Cherkashin, Rashida Orlova, Nikolay Vorobyov |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Stereotactic body radiation therapy medicine.medical_treatment Disease Adenocarcinoma Radiosurgery 03 medical and health sciences 0302 clinical medicine Pancreatic cancer Antineoplastic Combined Chemotherapy Protocols medicine Humans 030212 general & internal medicine Novel Treatment (New Drug/Intervention Established Drug/Procedure in New Situation) Aged Chemotherapy business.industry Liver Neoplasms Cancer General Medicine Metastatic Pancreatic Adenocarcinoma medicine.disease Combined Modality Therapy Magnetic Resonance Imaging Radiation therapy Pancreatic Neoplasms 030220 oncology & carcinogenesis Toxicity Female Radiology business Tomography X-Ray Computed |
| Zdroj: | BMJ Case Rep |
| ISSN: | 1757-790X |
| Popis: | Metastatic pancreatic cancer is characterised by poor prognosis. High toxicity of chemotherapy limits its use in elderly patients with severe comorbidities. Meanwhile, in metastatic disease, local treatment did not show the positive effect on life expectancy. We present a clinical case of a 72-year-old woman with metastatic pancreatic adenocarcinoma tumour, node, metastases (T3N0M1) (according to the seventh TNM classification of the International Union Against Cancer). Chemotherapy led to partial response, but later was stopped due to severe toxicity. Thereafter, consolidating radiosurgical treatment was performed. Dose to pancreatic and liver lesions was 35 Gy in five fractions. After 9 months, only one liver lesion and primary pancreatic tumour, stable in size were determined by MRI. At present time, the patient is alive and in good condition, the disease is stable 50 months after stereotactic body radiation therapy (SBRT). SBRT provides a high level of local control and in combination with systemic treatment can potentially increase survival. |
| Databáze: | OpenAIRE |
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