The solid state of anti-inflammatory morniflumate diniflumate: A cocrystalline salt

Autor: Maria Barrio, Jean-Marie Teulon, Ivo B. Rietveld, René Céolin, Josep-Lluís Tamarit, Christophe Guéchot, Hassan Allouchi, Benoît Robert
Přispěvatelé: Sciences et Méthodes Séparatives (SMS), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU), Universitat Politècnica de Catalunya. Departament de Física, Universitat Politècnica de Catalunya. GCM - Grup de Caracterització de Materials
Rok vydání: 2021
Předmět:
crystal structure
phase behaviour
Enthalpy
Salt
Anti-Inflammatory Agents
Molecular Conformation
Pharmaceutical Science
Salt (chemistry)
niflumic acid derivatives
Química farmacèutica
02 engineering and technology
010402 general chemistry
01 natural sciences
Cocrystal
Differential scanning calorimetry
Enginyeria química [Àrees temàtiques de la UPC]
Congruent melting
Niflumic acid derivatives
medicine
[CHIM.CRIS]Chemical Sciences/Cristallography
salt
cocrystal
chemistry.chemical_classification
Calorimetry
Differential Scanning
Hydrogen bond
Crystal structure
Niflumic acid
Niflumic Acid
021001 nanoscience & nanotechnology
0104 chemical sciences
[CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry
Crystallography
Phase behaviour
chemistry
Intramolecular force
Anti-inflammatory
0210 nano-technology
Pharmaceutical chemistry
medicine.drug
Zdroj: International Journal of Pharmaceutics
International Journal of Pharmaceutics, Elsevier, In press
UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)
ISSN: 1873-3476
0378-5173
Popis: International audience; Morniflumate diniflumate, a molecular compound involving niflumic acid and its bmorpholino ethyl ester (morniflumate) in the mole ratio 2:1, is found to crystallize in a triclinic P-1 space group with a unit-cell volume of 2203.4(5) Å 3. It is a cocrystal between a morniflumate + niflumatesalt and a neutral niflumic acid molecule. The co-crystalline salt forms endothermically with a positive excess volume and it melts incongruently at 382.3(8) K. Differential scanning calorimetry executed at heating rates above 20 K×min-1 , leads to congruent melting at 387.8(9)K with an enthalpy change of ∆fusH = 80(2) J g-1. The rare occurrence that incongruent and congruent melting can be observed for the same cocrystal may be due to the conformational versatility of the niflumic acid molecule and its slow conversion between the different conformations due to weak intramolecular hydrogen bonding.
Databáze: OpenAIRE
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