Kinetics of the action of three selenides on Staphylococcus aureus growth as studied by microcalorimetry
| Autor: | Liming Hu, Hui-Gang Liang, Yi Liu, Jun Wu, Liping Yang, Song-Sheng Qu |
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| Rok vydání: | 2002 |
| Předmět: |
Isothermal microcalorimetry
Staphylococcus aureus Endocrinology Diabetes and Metabolism Clinical Biochemistry Kinetics chemistry.chemical_element Calorimetry Bacterial growth medicine.disease_cause Biochemistry Medicinal chemistry Inorganic Chemistry chemistry.chemical_compound Reaction rate constant Selenide Organoselenium Compounds medicine Organic chemistry heterocyclic compounds Chemistry Biochemistry (medical) General Medicine Anti-Bacterial Agents Selenium |
| Zdroj: | Biological trace element research. 92(2) |
| ISSN: | 0163-4984 |
| Popis: | The effect of three kinds of selenide on Staphylococcus aureus growth was studied by means of microcalorimetry. Differences in their capacities to inhibit the metabolism of this bacterium were observed. The rate constant k (in the log phase) in the presence of the compounds decreased with increasing concentrations of the compounds. The relationship of k and c is nearly linear for the selenium compounds. Judged from the rate constant, k, and the half-inhibitory concentration IC50, the experimental results reveal that the sequence of antibiotic activity of the three tested selenides compounds is (2-hydroxy benzyl imino)ethyl n-hexyl selenide> n-butyl(2- hydroxy benzyl imino)ethyl selenide > bis[(2,4-dihydroxy benzyl imino)ethyl] selenide. |
| Databáze: | OpenAIRE |
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