Linkage relationship between TK and SV40 T-antigen genes in the SV40-transformed WI98VaD human cell line
| Autor: | M. Ermonval, A. Kay, M.A. Persuy, Andries Westerveld, H.G. Suarez, R. Cassingena |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Genetic Linkage
viruses Simian virus 40 Kidney Thymidine Kinase Chinese hamster Cell Line Mice Cricetulus Antigens Neoplasm Cricetinae Animals Chromosomes Human Humans Antigens Viral Tumor Gene Metaphase Antigens Viral Cells Cultured Skin biology Chromosome Cell Biology biology.organism_classification Cell Transformation Viral Molecular biology Genes Thymidine kinase Hypoxanthine-guanine phosphoribosyltransferase SV40 T-antigen Hypoxanthine Phosphoribosyltransferase |
| Zdroj: | Experimental cell research. 129(1) |
| ISSN: | 0014-4827 |
| Popis: | The transfer of isolated metaphase chromosomes from SV40-transformed WI 98 VaD human cells (SV40 T-Ag + ), to thymidine kinase deficient (TK − ) 3T3 mouse cells or hypoxanthine phosphoribosyltransferase deficient (HPRT − ) Chinese hamster cells (CHK), suggest that: in the WI 98 VaD cells SV40 is inserted at least in chromosome(s) 17, the carrier of the TK gene and that, in such cells, there is no linkage relationship between HPRT and SV40 T-Ag genes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|