| Autor: |
Yongchao, Guan, Meng, Zhang, Yingda, Wang, Zhongzhuo, Liu, Zelin, Zhao, Hong, Wang, Dingjie, An, Aidong, Qian, Yuanhuan, Kang, Wuwen, Sun, Xiaofeng, Shan |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Journal of Microbiology. 60:1153-1161 |
| ISSN: |
1976-3794 |
| DOI: |
10.1007/s12275-022-2373-8 |
| Popis: |
Aeromonas veronii is a pathogen which can induce diseases in humans, animals and aquatic organisms, but its pathogenic mechanism and virulence factors are still elusive. In this study, we successfully constructed a mutant strain (ΔascP) by homologous recombination. The results showed that the deletion of the ascP gene significantly down-regulated the expression of associated effector proteins in A. veronii compared to its wild type. The adhesive and invasive abilities of ΔascP to EPC cells were 0.82-fold lower in contrast to the wild strain. The toxicity of ΔascP to cells was decreased by about 2.91-fold (1 h) and 1.74-fold (2 h). Furthermore, the LD |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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