Cardiac function in children with premature ventricular contractions: the effect of omega-3 polyunsaturated fatty acid supplementation
| Autor: | Vedide Tavli, Murat Muhtar Yılmazer, Dildar Bahar Genc, Önder Doksöz, Taliha Öner, Rahmi Özdemir, Yilmaz Yozgat, Savaş Demirpençe, Timur Meşe, Barış Güven |
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| Přispěvatelé: | YOZGAT, YILMAZ |
| Rok vydání: | 2018 |
| Předmět: |
Cardiac function curve
Male medicine.medical_specialty Adolescent Heart Ventricles Cardiomyopathy 030204 cardiovascular system & hematology Placebo Ventricular Function Left 03 medical and health sciences 0302 clinical medicine Internal medicine Heart rate Fatty Acids Omega-3 medicine Humans cardiovascular diseases 030212 general & internal medicine Prospective Studies Child chemistry.chemical_classification medicine.diagnostic_test business.industry Fatty acid General Medicine medicine.disease Ventricular Premature Complexes chemistry Polyunsaturated fatty acid supplementation Echocardiography Case-Control Studies Child Preschool Pediatrics Perinatology and Child Health cardiovascular system Cardiology Electrocardiography Ambulatory Female Cardiology and Cardiovascular Medicine business Electrocardiography Anti-Arrhythmia Agents Polyunsaturated fatty acid |
| Zdroj: | Cardiology in the young. 28(7) |
| ISSN: | 1467-1107 1047-9511 |
| Popis: | BackgroundPremature ventricular contractions are accepted as benign in structurally normal hearts. However, reversible cardiomyopathy can sometimes develop. Omega-3 polyunsaturated fatty acids have anti-arrhythmic properties in animals and humans.AimWe evaluated left ventricular function in children with premature ventricular contractions with normal cardiac anatomy and assessed the impact of omega-3 fatty acid supplementation on left ventricular function in a prospective trial.MethodsA total of 25 patients with premature ventricular contraction, with more than 2% premature ventricular contractions on 24-hour Holter electrocardiography, and 30 healthy patients were included into study. All patients underwent electrocardiography, left ventricular M-mode echocardiography, and myocardial performance index testing. Patients with premature ventricular contraction were given omega-3 fatty acids at a dose of 1 g/day for 3 months, and control echocardiography and 24-hour Holter electrocardiography were performed. Neither placebo nor omega-3 fatty acids were given to the control group.ResultsCompared with the values of the control group, the patients with premature ventricular contraction had significantly lower fractional shortening. The myocardial performance index decreased markedly in the patient groups. The mean heart rate and mean premature ventricular contraction percentage of Group 2 significantly decreased in comparison with their baseline values after the omega-3 supplementation.ConclusionIn conclusion, premature ventricular contractions can lead to systolic cardiac dysfunction in children. Omega-3 supplementation may improve cardiac function in children with premature ventricular contractions. This is the first study conducted in children to investigate the possible role of omega-3 fatty acid supplementation on treatment of premature ventricular contractions. |
| Databáze: | OpenAIRE |
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