Cortisol urinary metabolites in dogs with hypercortisolism, congestive heart failure, and healthy dogs: pilot investigation
| Autor: | Stacey E. Parbhu, Eric B. Thorstensen, Nicolas Lopez-Villalobos, Arnon Gal, Richard K. Burchell, Ester Quilez, Karin Weidgraaf |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Hydrocortisone 040301 veterinary sciences Urinary system Pilot Projects 0403 veterinary science 03 medical and health sciences chemistry.chemical_compound Dogs Reference Values Internal medicine medicine Animals Tetrahydrocortisone Dog Diseases Prospective Studies Cushing Syndrome 030304 developmental biology Heart Failure 0303 health sciences General Veterinary business.industry 04 agricultural and veterinary sciences medicine.disease Cushing Disease Cross-Sectional Studies Endocrinology chemistry Heart failure NAD+ kinase Cortisone Brief Communications business medicine.drug |
| Zdroj: | J Vet Diagn Invest |
| ISSN: | 1943-4936 1040-6387 |
| Popis: | Nonadrenal diseases (NAD), including congestive heart failure (CHF), can affect the conversion of cortisone to cortisol favoring the production of cortisol’s urinary downstream metabolites 5α/5β-tetrahydrocortisol (THF) relative to tetrahydrocortisone (THE). We hypothesized that healthy dogs would have lower urinary levels of cortisol, cortisone, THF, and THE than dogs with hypercortisolism (HC) or CHF, and the latter would have higher urinary levels of THF and lower THE than dogs with HC. Four, 9, and 8 dogs with HC, CHF, and normal health, respectively, were included in a pilot prospective cross-sectional study. A single morning voided urine sample was analyzed for urinary cortisol metabolites by liquid chromatography–mass spectrometry. The percentages of conjugated urinary metabolites were significantly higher in dogs with CHF than in healthy dogs ( p = 0.001), and not different in HC dogs ( p = 0.07). Log-transformed urine cortisol metabolites–to–creatinine ratios in healthy dogs were significantly lower than the 2 other groups ( p |
| Databáze: | OpenAIRE |
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