Restless legs syndrome outside the blood–brain barrier – Exacerbation by domperidone in Parkinson's disease
| Autor: | V. Cochen De Cock, Sophie Bayard, Yves Dauvilliers, S. Rios Romenets, C. Galatas, Ronald B. Postuma, Christina Wolfson, B Carlander |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Parkinson's disease Exacerbation Disease 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Dopamine Restless Legs Syndrome Internal medicine mental disorders Prevalence medicine Humans Restless legs syndrome Aged business.industry Dopaminergic Parkinson Disease Middle Aged medicine.disease Domperidone Pathophysiology nervous system diseases 3. Good health body regions Treatment Outcome Endocrinology Neurology Blood-Brain Barrier Dopamine Antagonists Female Neurology (clinical) Geriatrics and Gerontology business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Parkinsonism & Related Disorders. 19:92-94 |
| ISSN: | 1353-8020 |
| DOI: | 10.1016/j.parkreldis.2012.07.019 |
| Popis: | Introduction: Models of dopaminergic function in restless legs focus on central dopaminergic neurons. Domperidone, a peripheral dopamine blocker that cannot cross the bloodebrain barrier, is commonly used in Parkinson’s disease. After encountering a case of restless legs syndrome that dramatically worsened with domperidone, we assessed whether Parkinson’s patients may have exacerbation of restless legs with domperidone. Methods: From two Parkinson’s disease cohorts, we assessed restless legs prevalence according to standard criteria, in patients taking vs. not taking domperidone. Regression analysis was performed, adjusting for age, sex, disease duration, UPDRS, dopaminergic medications and other medications. Results: One hundred eighty four patients were assessed, of whom 46 (25%) had restless legs. Thirteen out of twenty seven (48%) patients on domperidone had restless legs compared to 33/157 (21%) without (p ¼ 0.010). Other medications were not associated with restless legs. Conclusion: This unexpected finding suggests that dopaminergic neurons outside of the bloodebrain barrier may be important in restless legs syndrome pathophysiology. |
| Databáze: | OpenAIRE |
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