Glycosaminoglycans as key molecules in atherosclerosis: the role of versican and hyaluronan
| Autor: | Nikolaos Tsilimingas, Achilleas D. Theocharis, Athanasia P. Asimakopoulou, Filippos Triposkiadis, Ioannis Kanakis, Alberto Passi, Nikos K. Karamanos, Eugenia Karousou, Dimos Karangelis |
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| Rok vydání: | 2010 |
| Předmět: |
Atherosclerosis
glycosaminoglycans Decorin Dermatan Sulfate Biochemistry Dermatan sulfate Extracellular matrix Glycosaminoglycan chemistry.chemical_compound Versicans Drug Discovery medicine Animals Humans Chondroitin sulfate Hyaluronic Acid Macrovascular disease Glycosaminoglycans Pharmacology Extracellular Matrix Proteins biology Biglycan Organic Chemistry Chondroitin Sulfates medicine.disease Cell biology Extracellular Matrix carbohydrates (lipids) Lipoproteins LDL chemistry biology.protein Molecular Medicine Versican Proteoglycans |
| Zdroj: | Current medicinal chemistry. 17(33) |
| ISSN: | 1875-533X |
| Popis: | Cardiovascular disease is the largest cause of death in Western societies and it primarily results from atherosclerosis of large and medium-sized vessels. Atherosclerosis leads to myocardial infarction, when it occurs in the coronary arteries, or stroke, when it occurs in the cerebral arteries. Pathological processes involved in macrovascular disease include the accumulation of lipids which are retained by extracellular matrix (ECM) molecules, especially by the chondroitin sulfate/dermatan sulfate (CS/DS) proteoglycans (CS/DSPGs), such as versican, biglycan and decorin. The sulfation pattern of CS is a key player in protein interactions causing atherosclerosis. Several studies have shown that lipoproteins bind CSPGs via their glycosaminoglycan chains. Galactosaminoglycans, such as CS and DS, bind low density lipoproteins (LDL), affecting the role of these molecules in the arterial wall. In this article, the role of CS and versican in atherosclerosis and hyaluronan in atherogenesis as well as the up to date known mechanisms that provoke this pathological condition are presented and discussed. |
| Databáze: | OpenAIRE |
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