Pathologic Findings in Novel Influenza A (H1N1) Virus ('Swine Flu') Infection
Autor: | Abraham T. Philip, Sanjay Mukhopadhyay, Robert Stoppacher |
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Jazyk: | angličtina |
Rok vydání: | 2010 |
Předmět: |
Adult
Male Oseltamivir Pathology medicine.medical_specialty Lung pathology Orthomyxoviridae H1N1 virus Autopsy Fatal outcome medicine.disease_cause Antiviral Agents Oseltamivir (Tamiflu) Swine flu chemistry.chemical_compound Anatomic Pathology Influenza A Virus H1N1 Subtype Pandemic Novel influenza A virus Influenza Human medicine Influenza A virus Bronchopneumonia Humans Pulmonary pathology Diffuse alveolar damage Lung Hyperplasia biology business.industry Reverse Transcriptase Polymerase Chain Reaction Respiratory disease Bacterial virus diseases General Medicine Original Articles Middle Aged medicine.disease biology.organism_classification respiratory tract diseases chemistry Female business |
Zdroj: | American Journal of Clinical Pathology |
ISSN: | 1943-7722 0002-9173 |
Popis: | Although novel influenza A (H1N1) virus infection has assumed pandemic proportions, there are few reports of the pathologic findings. Herein we describe the pathologic findings of novel influenza A (H1N1) infection based on findings in 2 autopsy cases. The first patient, a 36-year-old man, had flu-like symptoms; oseltamivir (Tamiflu) therapy was started 8 days after onset of symptoms, and he died on day 15 of his illness. At autopsy, the main finding was diffuse alveolar damage with extensive fresh intra-alveolar hemorrhage. The second patient, a 46-year-old woman with alcoholism, was found unresponsive in a basement and brought to the hospital intoxicated and confused. Her condition deteriorated rapidly, and she died 4 days after admission. The main autopsy finding was acute bronchopneumonia with gram-positive cocci, intermixed with diffuse alveolar damage. The pathologic findings in these contrasting cases of novel influenza A (H1N1) infection are similar to those previously described for seasonal influenza. The main pathologic abnormality in fatal cases is diffuse alveolar damage, but it may be overshadowed by an acute bacterial bronchopneumonia. |
Databáze: | OpenAIRE |
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