| Autor: |
Wayne A. Phillips, Owen J. Sansom, Patrick O. Humbert, Peter R. Shepherd, Toby J. Phesse, Kaylene J. Simpson, Matthew J. Smalley, Richard W. Clarkson, Carleen Cullinane, Luc Furic, Sarah Koushyar, Arthi A. Macpherson, Richard J. Rebello, Karen G. Montgomery, Paul Waring, Christina M. Fennell, Valerie S. Meniel, Jason Li, Helen B. Pearson |
| Rok vydání: |
2023 |
| DOI: |
10.1158/2159-8290.22532960 |
| Popis: |
Supplementary Figure 7: Characterization of Pik3ca+/HR, Ptenfl/fl and Pik3ca+/HR;Ptenfl/fl prostate tumors. Representative images of IHC to detect (A) PCNA and (B) Cleaved-caspase 3 (CC3) in Pik3ca+/HR, Ptenfl/fl and Pik3ca+/HR;Ptenfl/fl prostate tissue 2 weeks post-castration compared to uncastrated, age-matched controls (scale bar: 50 um, n = 3). Mice were castrated when prostate carcinoma was prevalent; Pik3ca+/HR = 400 d old, Ptenfl/fl = 200 d old and Pik3ca+/HR;Ptenfl/fl =100 d old. Quantitative RT-PCR to detect (C) Nkx3.1 and (D) Pbsn mRNA in Wt prostate and Pik3ca+/HR, Ptenfl/fl and Pik3ca+/HR;Ptenfl/fl stage-matched prostate carcinomas (n = 5). Error bars: SEM, *P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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