Analysis of the prodynorphin promoter polymorphism in atopic dermatitis and disease-related pruritus
| Autor: | Elli K. Greisenegger, Fritz Zimprich, Georg Stingl, Tamara Kopp, Alexander Zimprich |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Allergy Genotype Down-Regulation Dermatology Dynorphin Disease Dermatitis Atopic Atopy Recurrence Immunopathology medicine Humans Protein Precursors Allele Promoter Regions Genetic skin and connective tissue diseases Opioid peptide Polymorphism Genetic integumentary system business.industry Pruritus Enkephalins Atopic dermatitis medicine.disease body regions Immunology Female business |
| Zdroj: | Clinical and Experimental Dermatology. 34:728-730 |
| ISSN: | 1365-2230 0307-6938 |
| DOI: | 10.1111/j.1365-2230.2009.03225.x |
| Popis: | Pruritus is one of the key symptoms in atopic dermatitis (AD). The prodynorphin polypeptide is a precursor protein of pruritus-modulating opioid peptides. It is encoded by the prodynorphin gene (PDYN). To investigate a possible correlation of PDYN promoter polymorphisms with intensity of pruritus in patients with AD, we genotyped 211 Austrian patients with AD and 197 nonatopic controls. No significant association of the PDYN promoter polymorphism with AD in general was found when patients with AD were compared with controls. The analysis of possible associations with pruritus intensity also showed no relevant difference in the allelic distribution between patients with different pruritus-score values. These data argue against an important role of the PDYN promoter polymorphism in AD in general and in the development of disease-related pruritus, although owing to our small sample size, a weak effect cannot be excluded. Additional studies are needed to further evaluate the influence of PDYN polymorphism in pruritus. |
| Databáze: | OpenAIRE |
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