The Association of Endothelin-1 with Markers of Arterial Stiffness in Black South African Women: The SABPA Study
| Autor: | Catharina M. C. Mels, Christine Susara du Plooy, Ruan Kruger, Hugo W. Huisman |
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| Rok vydání: | 2015 |
| Předmět: |
education.field_of_study
medicine.medical_specialty Article Subject business.industry Population General Medicine Arteriosclerosis medicine.disease Biochemistry Pulse pressure Compliance (physiology) Blood pressure Internal medicine Arterial stiffness medicine Cardiology education business Molecular Biology Pulse wave velocity Body mass index Research Article |
| Zdroj: | Journal of Amino Acids |
| ISSN: | 2090-0112 2090-0104 |
| DOI: | 10.1155/2015/481517 |
| Popis: | Background. Limited data exist regarding endothelin-1 (ET-1), a vasoactive contributor in vascular tone, in a population subjected to early vascular deterioration. We compared ET-1 levels and explored its association with markers of arterial stiffness in black and white South Africans. Methodology. This cross-sectional substudy included 195 black (men: n=99; women: n=95) and 197 white (men: n=99; women: n=98) South Africans. Serum ET-1 levels were measured as well as markers of arterial stiffness (blood pressure, pulse wave velocity, and arterial compliance). ET-1 levels were higher in black men and white women compared to their counterparts after adjusting for C-reactive protein. In both single and partial (adjusting for body mass index and gamma glutamyl transferase) regression analyses ET-1 correlated with age, interleukin-6, high density lipoprotein cholesterol, systolic blood pressure, pulse pressure, and pulse wave velocity in black women. In multivariate regression analyses the independent association of ET-1 with systolic blood pressure (Adj. R2=0.13; β=0.28, p<0.01) and pulse pressure (Adj. R2=0.11; β=0.27, p<0.01) was confirmed in black women only. ET-1 additionally associated with interleukin-6 in black women (p<0.01). Conclusion. Our result suggests that ET-1 and its link with subclinical arteriosclerosis are potentially driven by low-grade inflammation as depicted by the association with interleukin-6 in the black female cohort. |
| Databáze: | OpenAIRE |
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