HPV16E6-dependent c-fos expression contributes to AP-1 complex formation in SiHa cells
| Autor: | Nao Sunagawa, Thongsavanh Phonaphonh, Hiroyuki Takemoto, Akira Arasaki, Akira Matayoshi, Keiichi Arakaki, Hajime Sunakawa, Hai Kuang, Shinichiro Kina, Feixin Liang |
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| Rok vydání: | 2011 |
| Předmět: |
Article Subject
Immunology Complex formation Uterine Cervical Neoplasms Biology medicine.disease_cause c-Fos Protein expression Cell Line Tumor medicine lcsh:Pathology Cytotoxic T cell Humans Basal cell RNA Small Interfering Cancer Cell Biology Oncogene Proteins Viral Transforming Growth Factor alpha medicine.disease Molecular biology Cell biology Gene Expression Regulation Neoplastic Repressor Proteins Transcription Factor AP-1 AP-1 Complex biology.protein Female Proto-Oncogene Proteins c-fos Oxidative stress lcsh:RB1-214 Research Article |
| Zdroj: | Mediators of Inflammation Mediators of Inflammation, Vol 2011 (2011) |
| ISSN: | 1466-1861 |
| Popis: | To date, the major role of HPV16E6 in cancer has been considered to be its ability to inhibit the p53 tumor-suppressor protein, thereby thwarting p53-mediated cytotoxic responses to cellular stress signals. Here, we show that HPV16E6-dependent c-fos oncogenic protein expression contributes to AP-1 complex formation under oxidative stress in SiHa cells (HPV16-positive squamous cell carcinoma of the cervix). In addition, we examined the role of HPV16E6 in TGF-α-induced c-fos expression and found that the c-fos protein expression induced by TGF-αis HPV16E6 dependent. Thus, our results provide the first evidence that HPV16E6 contributes to AP-1 complex formation after both ligand-dependent and independent EGFR activation, suggesting a new therapeutic approach to the treatment of HPV-associated tumors. |
| Databáze: | OpenAIRE |
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