Phase behaviour of dehydrated phosphatidylcholines
| Autor: | Milan D. Antonijevic, Stephen A. Leharne, Samuel K. Owusu-Ware, Babur Z. Chowdhry |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
chemistry.chemical_classification
Liposome digestive oral and skin physiology technology industry and agriculture chemistry.chemical_element 02 engineering and technology Activation energy Polymer 010402 general chemistry 021001 nanoscience & nanotechnology Kinetic energy Condensed Matter Physics 01 natural sciences 0104 chemical sciences Colloid Crystallography Differential scanning calorimetry chemistry TA Phase (matter) lipids (amino acids peptides and proteins) Physical and Theoretical Chemistry 0210 nano-technology Carbon |
| ISSN: | 1388-6150 |
| Popis: | Dehydrated DLPC, DMPC, DPPC and DSPC have been characterised at temperatures below the diacyl carbon chain-melting transition (T m), using DSC. For the first time, the existence of pre-Tm transition processes, which are, usually, only observed in the colloidal/liposomal state of saturated phospholipids, has been detected for the dehydrated phosphatidylcholines. Temperature-modulated differential scanning calorimetry was used to characterise the several complexes, overlapping pre-T m transition processes. Kinetic studies of the chain-melting (T m) transition show the activation energy dependence on α (conversion rate), i.e. activation energy decreases as the transition progresses, pointing to the importance of initial cooperative (intra- and inter-molecular) mobility. Furthermore, the activation energy increases with increase in diacyl chain length of the phosphatidylcholines which supports the finding that greater molecular interactions of the polymer chain and its head groups in the dehydrated solid state lead to enhanced stability of dehydrated phosphatidylcholines. |
| Databáze: | OpenAIRE |
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