Red Wine, Resveratrol and Atrial Fibrillation
| Autor: | Melissa Medeiros Markoski, Eduardo Dytz Almeida, Laura Siga Stephan, Aline Marcadenti, Juliano Garavaglia |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
lcsh:TX341-641 Wine Review 030204 cardiovascular system & hematology Pharmacology Resveratrol Lower risk Antioxidants 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Cardiac conduction Atrial Fibrillation Stilbenes medicine Repolarization Animals Humans Myocytes Cardiac Risk factor Nutrition and Dietetics business.industry Cardiac arrhythmia food and beverages Polyphenols Atrial fibrillation medicine.disease trans-resveratrol 030104 developmental biology chemistry business lcsh:Nutrition. Foods and food supply Anti-Arrhythmia Agents Food Science |
| Zdroj: | Nutrients Nutrients, Vol 9, Iss 11, p 1190 (2017) |
| ISSN: | 2072-6643 |
| Popis: | Atrial fibrillation (AF) is a common cardiac arrhythmia that is associated with increased risk for cardiovascular disease and overall mortality. Excessive alcohol intake is a well-known risk factor for AF, but this correlation is less clear with light and moderate drinking. Besides, low doses of red wine may acutely prolong repolarization and slow cardiac conduction. Resveratrol, a bioactive polyphenol found in grapes and red wine, has been linked to antiarrhythmic properties and may act as an inhibitor of both intracellular calcium release and pathological signaling cascades in AF, eliminating calcium overload and preserving the cardiomyocyte contractile function. However, there are still no clinical trials at all that prove that resveratrol supplementation leads to improved outcomes. Besides, no observational study supports a beneficial effect of light or moderate alcohol intake and a lower risk of AF. The purpose of this review is to briefly describe possible beneficial effects of red wine and resveratrol in AF, and also present studies conducted in humans regarding chronic red wine consumption, resveratrol, and AF. |
| Databáze: | OpenAIRE |
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