Neuronal Morphology Generates High-Frequency Firing Resonance
| Autor: | Srdjan Ostojic, Vincent Hakim, German Szapiro, Boris Barbour, Eric J. Schwartz, Nicolas Brunel |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Neurons Membrane potential Cerebellum education.field_of_study Somatic cell General Neuroscience Population Purkinje cell Action Potentials Articles Biology Inhibitory postsynaptic potential Rats Purkinje Cells Electrophysiology Amplitude medicine.anatomical_structure medicine Animals Rats Wistar education Neuroscience |
| Zdroj: | The Journal of Neuroscience. 35:7056-7068 |
| ISSN: | 1529-2401 0270-6474 |
| DOI: | 10.1523/jneurosci.3924-14.2015 |
| Popis: | The attenuation of neuronal voltage responses to high-frequency current inputs by the membrane capacitance is believed to limit single-cell bandwidth. However, neuronal populations subject to stochastic fluctuations can follow inputs beyond this limit. We investigated this apparent paradox theoretically and experimentally using Purkinje cells in the cerebellum, a motor structure that benefits from rapid information transfer. We analyzed the modulation of firing in response to the somatic injection of sinusoidal currents. Computational modeling suggested that, instead of decreasing with frequency, modulation amplitude can increase up to high frequencies because of cellular morphology. Electrophysiological measurements in adult rat slices confirmed this prediction and displayed a marked resonance at 200 Hz. We elucidated the underlying mechanism, showing that the two-compartment morphology of the Purkinje cell, interacting with a simple spiking mechanism and dendritic fluctuations, is sufficient to create high-frequency signal amplification. This mechanism, which we term morphology-induced resonance, is selective for somatic inputs, which in the Purkinje cell are exclusively inhibitory. The resonance sensitizes Purkinje cells in the frequency range of population oscillations observedin vivo. |
| Databáze: | OpenAIRE |
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