BRCA1 and TOP2A gene amplification and protein expression in four molecular subtypes of breast cancer
| Autor: | Vladan P. Čokić, Dragoslava Djikić, Tijana Brekovic, Mirela Budeč, Vesna Koko, Olivera Mitrović, Mileva Mićić, Sanja Vignjević |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
TOP2A Gene
Biology General Biochemistry Genetics and Molecular Biology Protein expression 03 medical and health sciences 0302 clinical medicine Breast cancer FISH medicine molecular subtypes of breast cancer skin and connective tissue diseases lcsh:QH301-705.5 030304 developmental biology 0303 health sciences DNA topoisomerase II alpha Brca1 protein TOP2A Luminal b BRCA1 medicine.disease Molecular biology 3. Good health lcsh:Biology (General) 030220 oncology & carcinogenesis immunohistochemistry Cancer research Immunohistochemistry Fish General Agricultural and Biological Sciences |
| Zdroj: | Archives of Biological Sciences, Vol 65, Iss 2, Pp 511-518 (2013) Archives of Biological Sciences |
| ISSN: | 1821-4339 0354-4664 |
| Popis: | We studied TOP2A amplification (using FISH methods), and TOP2A and BRCA1 protein overexpression (immunohistochemistry) in four molecular subtypes of breast cancer. Of 53 patients, 32 showed TOP2A and 38 showed BRCA1 overexpression. The highest percentage of TOP2A amplification (47.8%) and deletion (13%) was detected in Luminal B subtypes. Of 11 Luminal B tumors with TOP2A amplification, 9 (81.8%) overexpressed TOP2A. BRCA1 protein overexpression showed significant positive correlation with TOP2A protein expression. BRCA1 and TOP2A proteins exhibited similar patterns of expression in Luminal B and triple-negative breast cancer, suggesting the same prognosis in those patients. [Projekat Ministarstva nauke Republike Srbije, br. 175053] |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|