A recombinant human collagen hydrogel for the treatment of partial-thickness burns: A prospective, self-controlled clinical study
| Autor: | Tong Liu, Bing Ma, Liu Xiaobin, Wenjia Hou, Chi Ben, Pan Bohan, Yanling Song, Haihang Li, Dasheng Cheng, Shen Tuo, Zhaofan Xia, Pengfei Luo, Shichu Xiao, Yu Sun, Shihui Zhu |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty China Adolescent Economic shortage Critical Care and Intensive Care Medicine law.invention Clinical study Pig skin 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine law medicine Humans Prospective Studies integumentary system business.industry Therapeutic effect 030208 emergency & critical care medicine General Medicine Middle Aged Surgery Clinical trial Emergency Medicine Recombinant DNA Female Collagen business Wound healing Burns Partial thickness Bandages Hydrocolloid |
| Zdroj: | Burns : journal of the International Society for Burn Injuries. 47(3) |
| ISSN: | 1879-1409 |
| Popis: | Introduction Allogeneic and xenogeneic skin are recognized as the best coverings for skin burn wounds, but currently face a supply shortage. To solve this problem, our research group developed a standardized manufactured hydrogel dressing based on a new type of highly bioactive recombinant human collagen. Study design Prospective self-controlled trial. Objective To evaluate the efficacy and safety of recombinant human collagen hydrogel in the treatment of partial burn wounds to the skin compared to those of xenogeneic skin. Methods This study included twenty-one patients admitted to Shanghai Changhai Hospital within 48 h after receiving partial-thickness skin burns. The wounds were symmetrically separated along the axis and treated with recombinant human collagen hydrogel (RHCH) or a human-CTLA4-Ig gene-transferred pig skin xenotransplant. The condition of the wound surfaces was recorded on days 0 (of enrollment), 5, 10, 15, and 20, and bacterial drug sensitivity testing, hematuria examination, and electrocardiographic tests were conducted on days 0, 10, 20, or on the day of wound healing. Results There were no statistically significant differences in wound healing time between the two groups. The median number of days to healing was 11.00 ± 0.56 for xenogeneic skin vs. 11.00 ± 1.72 for RHCH. Conclusion During the observation period, the therapeutic effect of the RHCH developed by our group on partial-thickness burn wounds was not significantly different from that of gene-transferred xenogeneic skin. Thus, our designed RHCH shows potential for clinical use to treat burn wounds on the skin. |
| Databáze: | OpenAIRE |
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