The ventral lateral posterior nucleus of the thalamus in schizophrenia: a post-mortem study
| Autor: | Peter Danos, Peter Falkai, Renate Stauch, Bernhard Bogerts, Hans Gert Bernstein, Bruno Baumann, Dieter Krell |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Psychosis viruses Thalamus Neuroscience (miscellaneous) Cell Count complex mixtures Brain mapping Reference Values Cerebellum Basal ganglia medicine Humans Radiology Nuclear Medicine and imaging Aged Cerebral Cortex Neurons Brain Mapping Ventral Thalamic Nuclei virus diseases Anatomy Middle Aged medicine.disease Psychiatry and Mental health medicine.anatomical_structure Cerebral cortex Schizophrenia Brain size Female Neuron Nerve Net Posterior Thalamic Nuclei Psychology |
| Zdroj: | Psychiatry Research: Neuroimaging. 114:1-9 |
| ISSN: | 0925-4927 |
| DOI: | 10.1016/s0925-4927(01)00131-7 |
| Popis: | The ventral lateral posterior thalamic nucleus (VLp) is an integral part of both the cerebello-thalamocortical and the basal ganglia-thalamocortical circuit. Although both circuits are thought to be involved in the pathophysiology of schizophrenia, the VLp has not yet been examined in schizophrenia. Using stereological techniques in the brains of eight patients with schizophrenia and in eight age- and sex-matched controls, we measured the nuclear volume of the VLp and obtained estimates of the total number of neurons in this nucleus. Whole brain volume did not differ between the schizophrenia group and the control group and was not correlated to the volume of the right VLp or left VLp. The volume (minus sign25%) and the total neuron number (minus sign27%) of the left VLp were significantly reduced in the schizophrenia group. There were no significant differences in the nuclear volume, neuron density and total neuron number in the right VLp between the schizophrenia group and the control group. There were no significant correlations between length of illness and the nuclear volume, neuron density and total neuron number of the left and right VLp. The present results suggest that the total neuron number of the left VLp is reduced in the schizophrenia group, which may reflect disturbed cerebello-thalamocortical and basal ganglia-thalamocortical circuits in this disease. |
| Databáze: | OpenAIRE |
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