Diagnostic accuracy of ganglion cell complex substructures in different stages of primary open-angle glaucoma
| Autor: | Amal M. Elbendary, Mohamed Hafez Abd El-latef, Kamal M. Enaam, Hisham Elsorogy |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Male Retinal Ganglion Cells Intraocular pressure medicine.medical_specialty Visual acuity genetic structures Open angle glaucoma Optic Disk Nerve fiber layer Visual Acuity Glaucoma Severity of Illness Index 03 medical and health sciences 0302 clinical medicine Nerve Fibers Ophthalmology medicine Humans Ganglion cell layer Intraocular Pressure business.industry Reproducibility of Results General Medicine Middle Aged medicine.disease eye diseases Ganglion 030104 developmental biology medicine.anatomical_structure Cross-Sectional Studies ROC Curve 030221 ophthalmology & optometry Visual Field Tests Female sense organs medicine.symptom Visual Fields business Glaucoma Open-Angle Tomography Optical Coherence Optic disc |
| Zdroj: | Canadian journal of ophthalmology. Journal canadien d'ophtalmologie. 52(4) |
| ISSN: | 1715-3360 |
| Popis: | Objective To evaluate diagnostic accuracy of substructure of ganglion cell complex versus peripapillary nerve fiber layer (NFL) thickness using spectral domain optical coherence tomography (SD-OCT) in different stages of glaucoma. Patients and Methods Thirty eyes were normal, 120 were glaucomatous. Glaucomatous eyes were classified into: early glaucoma (46), moderate glaucoma (48), and severe glaucoma (26). Perimetry and SD-OCT were done. Peripapillary NFL thickness, ganglion cell layer (GCL), macular NFL thickness, combined GCL and macular ganglion cell complex (GCC), were recorded. Area under receiver operating characteristic curves (AUCs) was used to verify performance of different OCT parameters. Results Peripapillary NFL, GCL, and GCC thickness values were significantly different in all stages of glaucoma. All comparisons were significantly different; normal versus early, early versus moderate and moderate versus severe. The best parameters that distinguished normal from early stage were: peripapillary NFL (AUC: 0.90), GCC (AUC: 0.75), early from moderate stage were: peripapillary NFL thickness (AUC: 0.85), GCL (0.81),GCC (0.81), moderate from severe stage were: GCC (AUC:0.95), macular NFL (AUC:0.91), GCL (AUC:0.89), and peripapillary NFL (AUC:0.88). Conclusions Peripapllary NFL and GCC thinning showed paradoxical course. The most diagnosed parameter in early glaucoma was peripapillary NFL and in severe glaucoma was GCC. In severe glaucoma, macular NFL showed higher diagnostic power than GCL and peripapillary NFL. Ganglion cell complex mapping may provide good alternative to optic disc imaging in advanced glaucoma with poor fixation. |
| Databáze: | OpenAIRE |
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