Gender differences in the relationship of anti-parvovirus B19 IgG with antinuclear antibody and C-reactive protein in clinical adult serum samples
| Autor: | Stanley J. Naides, Thomas A. O’Bryan |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Anti-nuclear antibody Adolescent viruses Immunology medicine.disease_cause Antibodies Viral Parvoviridae Infections Young Adult Blood serum Immune system Sex Factors Rheumatology hemic and lymphatic diseases medicine Parvovirus B19 Human Immunology and Allergy Humans Aged Aged 80 and over biology Parvovirus business.industry C-reactive protein virus diseases Immune dysregulation Middle Aged biology.organism_classification C-Reactive Protein Antibodies Antinuclear Immunoglobulin G biology.protein Biomarker (medicine) Female Antibody business Biomarkers |
| Zdroj: | Rheumatology international. 30(4) |
| ISSN: | 1437-160X |
| Popis: | Human parvovirus B19 (B19) infection is often suspected as an etiologic agent in a variety of rheumatologic diseases. It has been hypothesized that this virus potentially induces immune dysregulation by abnormal cytokine expression in susceptible hosts. The objective of this study is to examine the relationship between anti-parvovirus B19 IgG antibody (B19 IgG) and two common markers of immune dysregulation-antinuclear antibody (ANA) and C-reactive protein (CRP) in clinical sera. Qualitative B19 IgG antibody and levels of high-sensitivity CRP were determined in adult serum samples submitted to a university hospital clinical laboratory for ANA testing. Prevalence of B19 IgG was compared among groups by ANA status and CRP tertile. B19 IgG was detected in 72.3% of 318 samples. Among women above the first quartile of age (38 years), presence of B19 IgG was associated with CRP tertile rank (P = 0.008) and CRP levelsor =1 mg/L (P = 0.001) independent of age and ANA status. B19 IgG was less frequent in ANA-positive than ANA-negative womenor =38 years of age (P = 0.009). Viral antibody was not associated with either biomarker in men. These data suggest parvovirus B19 infection may be associated with chronic inflammation in some women after the third decade of life. |
| Databáze: | OpenAIRE |
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