Exploration of spatial distribution of brain metastasis from small cell lung cancer and identification of metastatic risk level of brain regions: a multicenter, retrospective study

Autor: Jingyi Shen, Baoyan Liu, Guixiang Weng, Shuanghu Yuan, Xin Gao, Rui Zhang, Meng Ni, Liu Zhou, Yujun Bai, Yong Wang, Wei Xia
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
Adult
Male
Pathology
medicine.medical_specialty
Lung Neoplasms
Population
R895-920
Hippocampus
Small-cell lung cancer
Temporal lobe
White matter
03 medical and health sciences
Medical physics. Medical radiology. Nuclear medicine
0302 clinical medicine
Medicine
Humans
Radiology
Nuclear Medicine and imaging
education
RC254-282
Aged
Retrospective Studies
Aged
80 and over
education.field_of_study
Radiological and Ultrasound Technology
medicine.diagnostic_test
business.industry
Brain Neoplasms
Putamen
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Magnetic resonance imaging
Brain metastases
General Medicine
Middle Aged
medicine.disease
Small Cell Lung Carcinoma
Location analysis
030104 developmental biology
medicine.anatomical_structure
Oncology
030220 oncology & carcinogenesis
Whole brain radiation therapy
Female
Brainstem
business
Brain metastasis
Research Article
Zdroj: Cancer Imaging, Vol 21, Iss 1, Pp 1-10 (2021)
Cancer Imaging
ISSN: 1470-7330
Popis: Objectives This study aimed to explore the spatial distribution of brain metastases (BMs) from small cell lung cancer (SCLC) a homogenous sample, and to identify the metastatic risk levels in brain regions. Methods T1-enhanced magnetic resonance imaging (MRI) from SCLC patients were retrospectively reviewed from three medical institutions in China. All images were registered to the standard brain template provided by the Montreal Neurological Institute (MNI) 152 database, followed by transformation of the location of all BMs to the space of standard brain. The MNI structural atlas and Anatomical Automatic Labeling (AAL) atlas were then used to identify the anatomical brain regions, and the observed and expected rates of BMs were compared using 2-tailed proportional hypothesis testing. The locations and sizes of brain lesions were analyzed after image standardization. Results A total of 215 eligible patients with 1033 lesions were screened by MRI, including 157 (73%) males and 58 (27%) females. The incidence of crucial structures were as follows: hippocampus 0.68%, parahippocampal 0.97%, brainstem 2.05%, cauate 0.68%, putamen 0.68%, pallidum 0.2%, thalamus 1.36%. No BMs were found in the amygdala, pituitary gland, or pineal gland. The cumulative frequency of the important structures was 6.62%. Based on the results of MNI structural atlas, the cerebellum, deep white matter and brainstem was identified as a higher risk region than expected for BMs (P = 9.80 ×10−15, 9.04 ×10−6), whereas temporal lobe were low-risk regions (P = 1.65 ×10−4). More detailed AAL atlas revealed that the low-risk regions for BMs was inferior frontal gyrus (P = 6.971 ×10−4), while the high-risk regions for BMs was cerebellar hemispheres (P = 1.177 ×10−9). Conclusion Many crucial structures including the hippocampus, parahippocampus, pituitary gland and thalamus etc. have low frequency of brain metastases in a population of SCLC patients. This study provides the help to investigate the clinical feasibility of HA-WBRT and non-uniform dose of PCI in a population of SCLC patients.
Databáze: OpenAIRE
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