Dietary administration of colesevelam hydrochloride does not affect fertility or reproductive performance in rats
| Autor: | Judith K. Marquis, Rafif Dagher, Michael R. Jones |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Litter (animal)
Male medicine.medical_specialty Dose Litter Size medicine.drug_class media_common.quotation_subject Colesevelam Hydrochloride Physiology Administration Oral Embryonic Development Fertility Biology Toxicology 030226 pharmacology & pharmacy Cholinergic Antagonists Allylamine Rats Sprague-Dawley 03 medical and health sciences Eating 0302 clinical medicine Bile acid sequestrant Pregnancy Internal medicine Toxicity Tests medicine Animals reproductive and urinary physiology media_common Dose-Response Relationship Drug Body Weight Sperm Spermatozoa Diet Rats Endocrinology 030220 oncology & carcinogenesis Sperm Motility Gestation Female Reproduction |
| Zdroj: | International journal of toxicology. 23(6) |
| ISSN: | 1091-5818 |
| Popis: | Colesevelam hydrochloride (HCl) (WelChol; Sankyo Pharma) is a novel, highly potent, bile acid-binding polymer used for the treatment of hypercholesterolemia. The primary aim of this study was to determine the effects of dietarily administered colesevelam HCl on fertility and reproductive performance parameters. To assess these effects, sexually mature Sprague-Dawley rats were randomized to one of five treatment groups: feed alone, feed plus control article (SigmaCell), or feed plus colesevelam HCl 200, 1000, or 2000 mg/kg/day. Male and female rats were administered the appropriate group agent for 28 and 15 days, respectively, and were subsequently paired together for cohabitation and mating. Females continued to receive the test agent in their dietary formulation through presumed gestation day (GD) 7. Presumed pregnant females underwent cesarean section on GD 20. Food consumption rate, body weight, gross necropsy, and standard preclinical tests for reproduction and fertility were performed for each test animal. No statistically significant differences were found between control and drug-treated groups for any tested endpoints of reproduction. All animals placed in cohabitation successfully mated. Uterine and litter end points were unaffected by dosages of colesevelam HCl as high as 2000 mg/kg/day. There were no significant differences between treatment group litter averages in the number of corpora lutea, implantation sites, litter size, live fetuses, body weights, early/late resorptions, and the number of dams with viable fetuses. In addition, no external alterations of fetal morphology were attributable to treatment with colesevelam HCl when administered up to the embryo implantation stage. In male animals, no significant differences were found between the colesevelam HCl and control study groups in the average caudal epididymal sperm count or sperm concentration, total number of motile and nonmotile sperm, and the total percentage of motile sperm. Based on these data, colesevelam HCl does not have any significant adverse reproductive or fertility effects in rats, even when administered at doses approximately 30 times greater than the approved clinical dose. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|