On the substrate specificity of enol ether formation in rat brain. Metabolism of O-alkyl ethanediol phosphorylethanolamine
| Autor: | Harald H.O. Schmid, Patricia C. Bandi, N. Chang, W.J. Baumann, T.H. Madson |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
chemistry.chemical_classification
Male Chromatography Gas Plasmalogen Stereochemistry Diol Biophysics Phospholipid Brain Ether Cell Biology Biochemistry Rats chemistry.chemical_compound chemistry Enol ether Animals lipids (amino acids peptides and proteins) Dehydrogenation Fatty Alcohols Molecular Biology Alkyl Bond cleavage Phospholipids Ethers |
| Zdroj: | Biochemical and biophysical research communications. 66(2) |
| ISSN: | 0006-291X |
| Popis: | 1- O -[1′-14C]Hexadecyl ethanediol 2-phosphorylethanolamine was administered to myelinating rat brain in order to establish general patterns of diol phospholipid metabolism and the specific substrate requirements of 1- O -alkyl 2-acyl sn -glycero-3-phosphorylethanolamine desaturase. It was shown that alkyl ethanediol PE was slowly metabolized by oxidative ether bond cleavage. Dehydrogenation to diol plasmalogen did not occur, thus providing further evidence for the high degree of substrate specificity of the desaturase present in brain. |
| Databáze: | OpenAIRE |
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