Durable Cognitive Gains and Symptom Improvement Are Observed in Individuals With Recent-Onset Schizophrenia 6 Months After a Randomized Trial of Auditory Training Completed Remotely
| Autor: | Tara A. Niendam, Seghel Yohannes, Felix Amirfathi, Rachel Loewy, Cameron S. Carter, Sophia Vinogradov, J. Daniel Ragland, Danielle A. Schlosser, Barbara K. Stuart, Melissa Fisher, Sisi Ma |
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| Rok vydání: | 2022 |
| Předmět: |
Adult
Male medicine.medical_specialty Psychosis Outcome Assessment 6.6 Psychological and behavioural Clinical Trials and Supportive Activities Medical and Health Sciences law.invention cognitive training Young Adult Physical medicine and rehabilitation Randomized controlled trial Double-Blind Method law Clinical Research Intervention (counseling) Outcome Assessment Health Care Behavioral and Social Science Medicine Humans Cognitive Dysfunction Young adult first-episode psychosis first-episodepsychosis Psychiatry business.industry Prevention Rehabilitation Psychology and Cognitive Sciences Evaluation of treatments and therapeutic interventions Cognition medicine.disease Serious Mental Illness recent-onset psychosis Cognitive training Cognitive Remediation Brain Disorders Health Care Psychiatry and Mental health Mental Health Psychotic Disorders Cognitive remediation therapy Schizophrenia Female business Regular Articles Follow-Up Studies |
| Zdroj: | Schizophrenia bulletin, vol 48, iss 1 Schizophr Bull |
| Popis: | Objective Cognitive impairment in schizophrenia predicts functional outcomes and is largely unresponsive to pharmacology or psychotherapy; it is thus a critical unmet treatment need. This article presents the impact of remotely completed, intensive, targeted auditory training (AT) vs control condition computer games (CG) in a double-blind randomized trial in young adults with recent-onset schizophrenia. Method Participants (N = 147) were assessed for cognition, symptoms, and functioning at baseline, post-intervention, and at 6-month follow-up. All participants were provided with laptop computers and were instructed to complete 40 hours remotely of training or computer games. An intent-to-treat analysis (N = 145) was performed using linear mixed models with time modeled as a continuous variable. Planned contrasts tested the change from baseline to post-training, baseline to 6-month follow-up, and post-training to 6-month follow-up. Results Global Cognition, which had improved in the AT group relative to the CG group at post-training, showed durable gains at 6-month follow-up in an omnibus group-by-time interaction test (F(1,179) = 4.80, P = .030), as did Problem-Solving (F(1,179) = 5.13, P = .025), and Speed of Processing improved at trend level significance (F(1,170) = 3.80, P = .053). Furthermore, the AT group showed significantly greater improvement than the CG group in positive symptoms (F(1,179) = 4.06, P = .045). Conclusions These results provide the first evidence of durable cognitive gains and symptom improvement at follow-up of cognitive training (CT) in early schizophrenia completed independently and remotely. While functioning did not show significant improvement, these findings suggest that intensive targeted CT of auditory processing is a promising component of early intervention to promote recovery from psychosis. |
| Databáze: | OpenAIRE |
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