Epidermal Growth Factor Receptor and K-RAS status in two cohorts of squamous cell carcinomas

Autor:	Jo Van Dorpe, Filip Baert, Marc Peeters, Pieter Demetter, Jean-Luc Van Laethem, Nadine Van Roy, Alain Bols, Patrick Pauwels, Nancy Van Damme, Franki Speleman, Philippe Deron
Jazyk:	angličtina
Předmět:	Male Pathology Cancer Research Tonsillar Neoplasms DNA Mutational Analysis Anal Canal Gene mutation Polymerase Chain Reaction Anus Neoplasms -- genetics -- metabolism -- pathology Cohort Studies Exon NECK-CANCER Belgium Anal Canal -- chemistry -- pathology Carcinoma Squamous Cell -- genetics -- metabolism -- pathology ras Proteins -- genetics Medicine and Health Sciences Tonsillar Neoplasms -- genetics -- metabolism -- pathology Epidermal growth factor receptor In Situ Hybridization Fluorescence Aged 80 and over ACTIVATING MUTATIONS ANAL CANCER Tonsil carcinoma Exons Anal canal Middle Aged lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Anus Neoplasms Immunohistochemistry ErbB Receptors medicine.anatomical_structure Oncology Carcinoma Squamous Cell Female GENE-MUTATIONS Research Article Adult Proto-Oncogene Proteins -- genetics medicine.medical_specialty Molecular Sequence Data Receptor Epidermal Growth Factor -- analysis -- genetics Biology lcsh:RC254-282 Proto-Oncogene Proteins p21(ras) LUNG-CANCER Proto-Oncogene Proteins Biomarkers Tumor medicine Genetics Anal cancer Humans HEAD Lung cancer Aged EGFR KINASE DOMAIN Base Sequence HUMAN-PAPILLOMAVIRUS Gene Amplification Médecine pathologie humaine medicine.disease Tumor Markers Biological -- analysis -- genetics METASTATIC COLORECTAL-CANCER COPY NUMBER Anatomopathologie Tonsil Mutation ras Proteins biology.protein
Zdroj:	BMC cancer, 10 BMC Cancer BMC Cancer, Vol 10, Iss 1, p 189 (2010) BMC CANCER
ISSN:	1471-2407
DOI:	10.1186/1471-2407-10-189
Popis:	With the availability of effective anti-EGFR therapies for various solid malignancies, such as non-cell small lung cancer, colorectal cancer and squamous cell carcinoma of the head and neck, the knowledge of EGFR and K-RAS status becomes clinically important. The aim of this study was to analyse EGFR expression, EGFR gene copy number and EGFR and K-RAS mutations in two cohorts of squamous cell carcinomas, specifically anal canal and tonsil carcinomas. Journal Article Multicenter Study Research Support, Non-U.S. Gov't SCOPUS: ar.j info:eu-repo/semantics/published
Databáze:	OpenAIRE
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