GPR43 regulates sodium butyrate-induced angiogenesis and matrix remodeling

Autor:	Charles R. Mackay, Véronique J. Moulin, Mark Slevin, Lucas Felipe Fernandes Bittencourt, Pollyana Ribeiro Castro, Lucíola S. Barcelos, SP Silvia Passos Andrade Andrade, Sébastien Larochelle
Rok vydání:	2020
Předmět:	0301 basic medicine Male Surgical Sponges Matrix remodeling Physiology Angiogenesis Neovascularization Physiologic Cell Line Receptors G-Protein-Coupled Extracellular matrix Transforming Growth Factor beta1 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Cell Movement Physiology (medical) medicine Animals Humans Receptor Cell Proliferation Mice Knockout Low dose Granulation tissue Sodium butyrate Fibroblasts Cell biology Extracellular Matrix Mice Inbred C57BL Disease Models Animal 030104 developmental biology medicine.anatomical_structure chemistry 030220 oncology & carcinogenesis Granulation Tissue Butyric Acid Angiogenesis Inducing Agents Collagen Cardiology and Cardiovascular Medicine
Zdroj:	American journal of physiology. Heart and circulatory physiology. 320(3)
ISSN:	1522-1539
Popis:	Butyrate is a short-chain fatty acid (SCFA) derived from microbiota and is involved in a range of cell processes in a concentration-dependent manner. Low concentrations of sodium butyrate (NaBu) were shown to be proangiogenic. However, the mechanisms associated with these effects are not yet fully known. Here, we investigated the contribution of the SCFA receptor GPR43 in the proangiogenic effects of local treatment with NaBu and its effects on matrix remodeling using the sponge-induced fibrovascular tissue model in mice lacking the
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::346cdce6e4ed53cfd4a2e350641ed34c https://pubmed.ncbi.nlm.nih.gov/33356962 Zobrazit plný text záznamu