GENETIC DIFFERENCES IN THE CORTISOL CONCENTRATION OF THE ADRENAL AND OTHER TISSUES OF WHITE AND COLOURED GUINEA-PIGS

Autor:	W. Gaus, A. T. A. Fazekas, W. M. Teller, J. Homoki
Rok vydání:	1975
Předmět:	Male medicine.medical_specialty Genotype Hydrocortisone Pigmentation Endocrinology Diabetes and Metabolism Guinea Pigs Age Factors Biology White (mutation) Sex Factors Endocrinology Liver Internal medicine Adrenal Glands medicine Animals Female
Zdroj:	Journal of Endocrinology. 66:159-164
ISSN:	1479-6805 0022-0795
DOI:	10.1677/joe.0.0660159
Popis:	SUMMARY The effect of genetic difference (white v. coloured) on the cortisol content of ten different organs and tissues, including the adrenals, of white and coloured guinea-pigs of both sexes and of different ages was studied by protein-binding techniques. Tissue cortisol concentration was significantly higher in all the tissues and adrenals of white animals of both sexes compared with coloured animals. The difference in tissue cortisol content between white and coloured animals was higher before (range 41·5–134·%) than after puberty (range 10·1–82·5%). The age-dependent decrease of cortisol concentration in different tissues and adrenals in adults was more marked in white guinea-pigs of both sexes (mean 30·6%, range 0·0–71·5%) than in coloured (mean 16·9%, range 0·0–63·1%). In adult animals the liver contained significantly 11·8–36·4%) more cortisol than in prepubertal animals. This pattern was the same in white and coloured guinea-pigs of both sexes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::346bc011ad798b6fd9bce2c92aca5c53 https://doi.org/10.1677/joe.0.0660159 Zobrazit plný text záznamu