A terapia antiplaquetária na alta hospitalar e prognóstico a longo prazo na síndrome de Takotsubo: dados do Registro Nacional Espanhol (RETAKO)
| Autor: | Pereyra, Eduardo, Fernández-Rodríguez, Diego, González-Sucarrats, Silvia, Almendro-Delia, Manuel, Martín, Agustín, de Miguel, Irene Martin, Andrés, Mireia, Duran-Cambra, Alberto, Sánchez-Grande-Flecha, Alejandro, Worner-Diz, Fernando, Núñez-Gil, Iván J, RETAKO investigators |
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| Přispěvatelé: | Institut Català de la Salut, [Pereyra E, González-Sucarrats S] Department of Cardiology, Hospital Universitario Arnau de Vilanova, Lleida, Spain. [Fernández-Rodríguez D] Hospital Universitari Arnau de Vilanova, Lleida, Spain. [Almendro-Delia M] Department of Cardiology, Hospital Virgen de la Macarena, Sevilla, Spain. [Martín A] Department of Cardiology, Hospital Universitario de Salamanca, Salamanca, Spain. [Martin de Miguel I] Department of Cardiology, Hospital Gregorio Marañón, Madrid, Spain. [Andrés M] Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Síndrome de Takotsubo
Agregação de plaquetas Otros calificadores::/uso terapéutico [Otros calificadores] acciones y usos químicos::acciones farmacológicas::usos terapéuticos::fármacos hematológicos::inhibidores de la agregación plaquetaria [COMPUESTOS QUÍMICOS Y DROGAS] Antiplatelet treatment Other subheadings::/therapy [Other subheadings] Catecolaminas enfermedades cardiovasculares::enfermedades cardíacas::disfunción ventricular::disfunción ventricular izquierda::miocardiopatía de Takotsubo [ENFERMEDADES] Catecholamines Tratamento antiplaquetário Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Hematologic Agents::Platelet Aggregation Inhibitors [CHEMICALS AND DRUGS] Cardiovascular Diseases::Heart Diseases::Ventricular Dysfunction::Ventricular Dysfunction Left::Takotsubo Cardiomyopathy [DISEASES] Platelet aggregation Endothelial dysfunction Other subheadings::/therapeutic use [Other subheadings] Disfunção endotelial Cardiology and Cardiovascular Medicine Takotsubo syndrome Plaquetes sanguínies - Inhibidors - Ús terapèutic Otros calificadores::/terapia [Otros calificadores] Miocardi - Malalties - Tractament |
| Zdroj: | Scientia |
| Popis: | Síndrome de Takotsubo; Disfunción endotelial; Tratamiento antiplaquetario Síndrome de Takotsubo; Disfunció endotelial; Tractament antiplaquetari Takotsubo syndrome; Endothelial dysfunction; Antiplatelet treatment Introduction Endothelial dysfunction and platelet activation have been highlighted as possible mediators in Takotsubo syndrome (TTS). Nevertheless, to date, evidence on the usefulness of antiplatelet therapy in TTS remains controversial. The aim of our study is to evaluate long-term prognosis in TTS patients treated with antiplatelet therapy (APT) at hospitalization discharge. Material and methods An ambispective cohort study from the Spanish National Takotsubo Registry database was performed (June 2002 to March 2017). Patients were divided into two groups: those who received APT at hospital discharge (APT cohort) and those who did not (non-APT cohort). Primary endpoint was all-cause death. Secondary endpoints included the composite of recurrence or readmission and a composite of death, recurrence or readmission. Results From a total of 741 patients, 728 patients were alive at discharge. Follow-up was performed in 544 patients, who were included in the final analysis: 321 patients (59.0%) in the APT cohort and 223 patients (41.0%) in the non-APT cohort. The APT cohort had a better clinical presentation and received more heart failure and acute coronary syndrome-like therapies (angiotensin converting enzyme inhibitors/angiotensin receptor blockers: 75.1% vs. 51.1%; p |
| Databáze: | OpenAIRE |
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