Genetic characterisation of African swine fever virus from 2017 outbreaks in Zambia: Identification of p72 genotype II variants in domestic pigs
| Autor: | Frank Banda, Andrew Chinyemba, Chitwambi Makungu, Lynnfield E. Mooya, Aaron S. Mweene, Yona Sinkala, Herman M. Chambaro, Gift Munthali, Ayato Takada, Simbarashe Chitanga, Paul Fandamu, Edgar Simulundu, Joseph Ndebe |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Veterinary medicine Genotype 040301 veterinary sciences Swine Sus scrofa Zambia Biology Genetic analysis African swine fever virus molecular epidemiology Virus Disease Outbreaks 0403 veterinary science 03 medical and health sciences Research Communication Genetic variation domestic pigs Animals African Swine Fever Genotyping Phylogeny lcsh:Veterinary medicine General Veterinary Molecular epidemiology Outbreak Genetic Variation 04 agricultural and veterinary sciences General Medicine Sequence Analysis DNA biology.organism_classification African Swine Fever Virus 030104 developmental biology genotyping lcsh:SF600-1100 |
| Zdroj: | The Onderstepoort Journal of Veterinary Research Onderstepoort Journal of Veterinary Research, Vol 85, Iss 1, Pp e1-e5 (2018) Onderstepoort Journal of Veterinary Research, Volume: 85, Issue: 1, Pages: 1-5, Published: 2018 |
| ISSN: | 2219-0635 |
| Popis: | African swine fever (ASF) is a contagious haemorrhagic disease associated with causing heavy economic losses to the swine industry in many African countries. In 2017, Zambia experienced ASF outbreaks in Mbala District (Northern province) and for the first time in Isoka and Chinsali districts (Muchinga province). Meanwhile, another outbreak was observed in Chipata District (Eastern province). Genetic analysis of part of the B646L gene, E183L gene, CP204L gene and the central variable region of the B602L gene of ASF virus (ASFV) associated with the outbreaks in Mbala and Chipata districts was conducted. The results revealed that the ASFV detected in Mbala District was highly similar to that of the Georgia 2007/1 isolate across all the genome regions analysed. In contrast, while showing close relationship with the Georgia 2007/1 virus in the B646L gene, the ASFV detected in Chipata District showed remarkable genetic variation in the rest of the genes analysed. These results suggest that the Georgia 2007/1-like virus could be more diverse than what was previously thought, underscoring the need of continued surveillance and monitoring of ASFVs within the south-eastern African region to better understand their epidemiology and the relationships between outbreaks and their possible origin. |
| Databáze: | OpenAIRE |
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