Immunohistochemical evaluation of cathepsin D in normal, hyperplastic and malignant endometrium: Correlation with hormone receptor status c-erbB-2, p53, Rb proteins and proliferation associated indices

Autor: N Zagorianakou, S. Tzioras, E. Ioachim, E. Kitsiou, K. Charalabopoulos, Antigony Mitselou, Marios Salmas, G. Makrydimas
Rok vydání: 2003
Předmět:
Adult
Receptors
Steroid
Pathology
medicine.medical_specialty
Stromal cell
Receptors
Steroid/immunology
Cell
Cathepsin D
Endometrium
medicine
Endometrial Neoplasms/*immunology/pathology
Humans
Cell Transformation
Neoplastic/*immunology
Neoplasm Staging
Carcinoma
Endometrioid/*immunology/pathology
biology
Endometrial Hyperplasia/*immunology/pathology
business.industry
Nuclear Proteins
Obstetrics and Gynecology
Precancerous Conditions/*immunology/pathology
Cathepsin D/biosynthesis/*immunology
Middle Aged
Hyperplasia
Prognosis
medicine.disease
Immunohistochemistry
Endometrial Neoplasms
Neoplasm Proteins
Proliferating cell nuclear antigen
Cell Transformation
Neoplastic
medicine.anatomical_structure
Oncology
Hormone receptor
Endometrial Hyperplasia
biology.protein
Cancer research
Nuclear Proteins/immunology
Female
Neoplasm Proteins/immunology
business
Carcinoma
Endometrioid
Precancerous Conditions
Zdroj: International Journal of Gynecological Cancer. 13:344-351
ISSN: 1525-1438
1048-891X
DOI: 10.1046/j.1525-1438.2003.13181.x
Popis: The immunohistochemical expression of cathepsin D was performed in paraffin embedded tissue from 79 endometrial carcinomas, 35 cases of hyperplasia, and 32 normal endometrium using the streptavidin-biotin method to investigate the role of cathepsin D (CD) in these lesions and its possible relationship with other potential and established prognostic markers. The association between CD and the other markers was assessed by univariate analysis. Tumor cell CD expression was lower in the group of carcinomas compared to the normal proliferative (P = 0.022) and secretory endometrium (P = 0.0005). In addition, hyperplastic cell CD expression was lower compared with epithelial cell CD expression in the secretory phase of normal endometrium (P = 0.009). Malignant cell CD expression was inversely correlated with tumor stromal cells (P = 0.007). A positive relationship of stromal cell CD expression with pRb (P = 0.046) and PCNA score (P < 0.0001) was detected in the group of carcinomas. In the proliferative phase of normal endometrium, epithelial CD expression was positively correlated with estrogen status (P = 0.015). The data show that down-regulation of CD expression is an early event in endometrial carcinogenesis. In addition, stromal cell CD expression may be involved in cell growth process in endometrial carcinomas. Int J Gynecol Cancer
Databáze: OpenAIRE
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