Immunotherapeutic potential of Crotoxin: anti-inflammatory and immunosuppressive properties
| Autor: | Marco A. Sartim, Danilo L. Menaldo, Suely Vilela Sampaio |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
lcsh:Arctic medicine. Tropical medicine medicine.drug_class lcsh:RC955-962 Inflammation Venom Review Pharmacology Toxicology Crotalus durissus terrificus Anti-inflammatory 03 medical and health sciences Therapeutic approach Immune system lcsh:RA1190-1270 lcsh:Zoology medicine Adaptative immunity South American rattlesnake lcsh:QL1-991 lcsh:Toxicology. Poisons Innate immunity Innate immune system biology biology.organism_classification Crotoxin 030104 developmental biology Infectious Diseases Animal Science and Zoology Parasitology medicine.symptom |
| Zdroj: | Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 24, Iss 1, Pp 1-13 (2018) Journal of Venomous Animals and Toxins including Tropical Diseases v.24 2018 The Journal of venomous animals and toxins including tropical diseases Universidade Estadual Paulista (UNESP) instacron:UNESP The Journal of Venomous Animals and Toxins Including Tropical Diseases |
| ISSN: | 1678-9199 |
| Popis: | For the past 80 years, Crotoxin has become one of the most investigated isolated toxins from snake venoms, partially due to its major role as the main toxic component in the venom of the South American rattlesnake Crotalus durissus terrificus. However, in the past decades, progressive studies have led researchers to shift their focus on Crotoxin, opening novel perspectives and applications as a therapeutic approach. Although this toxin acts on a wide variety of biological events, the modulation of immune responses is considered as one of its most relevant behaviors. Therefore, the present review describes the scientific investigations on the capacity of Crotoxin to modulate anti-inflammatory and immunosuppressive responses, and its application as a medicinal immunopharmacological approach. In addition, this review will also discuss its mechanisms, involving cellular and molecular pathways, capable of improving pathological alterations related to immune-associated disorders. |
| Databáze: | OpenAIRE |
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