3,5-Bis(trifluoromethyl)phenyl sulfones in the modified Julia olefination: application to the synthesis of resveratrol

Autor:	Diego A. Alonso, Carmen Nájera, Montserrat Varea
Rok vydání:	2004
Předmět:	chemistry.chemical_classification Trifluoromethyl Julia olefination Organic Chemistry General Medicine Resveratrol Biochemistry Medicinal chemistry chemistry.chemical_compound chemistry Drug Discovery Organic chemistry Stereoselectivity Phosphazene Alkyl Carbanion
Zdroj:	Tetrahedron Letters. 45:573-577
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2003.10.196
Popis:	The reaction between carbanions derived from alkyl 3,5-bis(trifluoromethyl)phenyl sulfones and aldehydes, affords with good yields and stereoselectivities the corresponding 1,2-disubstituted alkenes through the Julia–Kocienski olefination reaction. This one-pot protocol can be performed using KOH at room temperature or the phosphazene base P4- t -Bu at −78 °C, and has been successfully used in a high yielding and stereoselective synthesis of various stilbenes such as resveratrol.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34608269d9f6b4c8af7297d1712f35d8 https://doi.org/10.1016/j.tetlet.2003.10.196 Zobrazit plný text záznamu Full Text from ScienceDirect