Thyroglobulin messenger ribonucleic acid levels in the peripheral blood of children with benign and malignant thyroid disease
| Autor: | Yvonne G. Lukes, Barbara L. Solomon, Gary L. Francis, Cydney Fenton, Aneeta Patel, Jefferey S. Anderson, R. Michael Tuttle, Matthew D. Ringel |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty endocrine system diseases Adolescent medicine.medical_treatment Thyroglobulin Papillary thyroid cancer Internal medicine Blood plasma medicine Biomarkers Tumor Humans RNA Messenger Thyroid Neoplasms Child Thyroid cancer Whole blood business.industry Thyroid disease Thyroid medicine.disease Pathophysiology Endocrinology medicine.anatomical_structure Child Preschool Pediatrics Perinatology and Child Health Female business |
| Zdroj: | Pediatric research. 49(3) |
| ISSN: | 0031-3998 |
| Popis: | Reverse transcriptase-PCR has identified thyroglobulin mRNA (Tg mRNA) in peripheral blood of normal adults and adults with thyroid cancer. However, no children were studied. The primary objective of this study was to determine whether whole blood Tg mRNA levels differ between benign and malignant thyroid disease in children. The secondary goals were to determine whether whole blood Tg mRNA levels vary with age or pubertal development among children with thyroid disease. Whole blood Tg mRNA levels were determined in 38 children (29 girls, nine boys; median age, 14.5 y; range, 4.8-20.4 y) with benign and malignant thyroid disease and correlated with diagnosis, age, pubertal status, thyroid size, and serum levels of free thyroxine, TSH, and Tg protein. Tg mRNA levels ranged from 3.3 to 104 pg Eq/microg total thyroid RNA (mean, 28 +/- 20.2 pg Eq/microg total thyroid RNA) and were similar in benign and malignant disorders (p = 0.67). However, in children with previously treated papillary thyroid cancer, Tg mRNA levels directly correlated with total body (131)I uptake (p = 0.026) and serum Tg protein (p = 0.037). There was no difference between boys and girls, and no change with pubertal maturation. In children with benign thyroid disease, Tg mRNA levels correlated with serum TSH (p = 0.031), but not with diagnosis, age, Tanner stage, or thyroid size. We conclude that Tg mRNA levels are similar in children with benign and malignant thyroid disease and unchanged by age or pubertal status, but correlated with tumor burden in previously treated papillary thyroid cancer. |
| Databáze: | OpenAIRE |
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