ATP dependent primary active transport of xenobiotic-glutathione conjugates by human erythrocyte membrane
| Autor: | Yogesh C. Awasthi, L. W. Wronski, Satish K. Srivastava, Edward F. Labelle, Shivendra V. Singh, Hassan Ahmad |
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| Rok vydání: | 1989 |
| Předmět: |
ATPase
Clinical Biochemistry Biological Transport Active chemical and pharmacologic phenomena Xenobiotics chemistry.chemical_compound Adenosine Triphosphate F-ATPase Humans Molecular Biology Adenosine Triphosphatases biology organic chemicals Erythrocyte Membrane Osmolar Concentration Temperature hemic and immune systems Cell Biology General Medicine Glutathione Enzyme Activation Membrane chemistry Biochemistry Active transport biology.protein Dinitrophenyl Xenobiotic Conjugate |
| Zdroj: | Molecular and Cellular Biochemistry. 91:131-136 |
| ISSN: | 1573-4919 0300-8177 |
| DOI: | 10.1007/bf00228088 |
| Popis: | We have demonstrated the presence of a dinitrophenyl glutathione (Dnp-SG) stimulated ATPase in human erythrocyte membranes. This ATPase mediates the active transport of glutathione — xenobiotic conjugate such as Dnp-SG from erythrocytes into the plasma. It is suggested that this transport system is distinct from the system which actively transports oxidized glutathione from the erythrocytes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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