1,7-asymmetric induction in a nitrogen ring expansion process facilitated by in situ tethering

Autor:	Jeffrey Aubé, Kelly Wayne Furness
Předmět:	In situ Chemistry Tethering Stereochemistry Cyclohexanones Nitrogen Organic Chemistry Caprolactam chemistry.chemical_element Stereoisomerism Ring (chemistry) Biochemistry Asymmetric induction chemistry.chemical_compound Polymer chemistry Schmidt reaction Physical and Theoretical Chemistry
Zdroj:	Scopus-Elsevier
Popis:	[formula: see text] There are only a few methods for the asymmetric ring expansion of prochiral ketones. Symmetrically substituted cyclohexanones can be converted to the corresponding ring-expanded caprolactam with excellent 1,7-diastereoselectivity (or = 93% ds) and yields (or = 86%), using a chiral hydroxy azide-mediated Schmidt reaction.
Databáze:	OpenAIRE
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